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• W2155302012 abstract "The effects of interleukin on testicular steroidogenesis have been studied in several laboratories, most often by using cultured rat Leydig cells. Several reports have indicated that interleukin-1β (IL-1β), but not interleukin-1α (IL-1α), exert a potent effect on gonadotropin action in rat Leydig cells. By using cultured porcine Leydig cells as a model, we found that IL-1α (and to a lesser extent IL-1β), contrary to previous reports, is a potent inhibitor of LH/hCG steroidogenic action; and we further localized the steroidogenic biochemical step(s) affected by IL-1α. IL-1α inhibited hCG-induced testosterone secretion (about 67%) in a dose- and time-dependent manner. Half maximal and maximal effects were obtained with 4 U/ml (~ 0.4 ng/ml, 0.3 × 10−10 M) and 20 U/ml (~ 2 ng/ml, 1.4 × 10−10 M) of IL-1α, respectively. The inhibitory effect of IL-1α on gonadotropin action was detected at 6 h and was maximal after 24 h of treatment with the cytokine. The IL-1α inhibitory effect was more potent than that of IL-1β: the maximal inhibitory effect of IL-1β was obtained with 400 U/ml. Subsequent investigations indicated that IL-1α inhibited different biochemical steps involved in gonadotropin-induced testicular steroidogenesis. In this context, although IL-1α appears to inhibit Leydig cell membrane functions (through a decrease in LH/hCG binding and gonadotropin-induced cAMP production), the antigonadotropin action of the cytokine is probably exerted predominantly at a step(s) located beyond cAMP formation. Indeed, the cytokine exerted its potent and significant (p < 0.001) inhibitory effect on testosterone formation in a similar manner when Leydig cells were stimulated with hCG (3 ng/ml, 3 h) or with 8-bromo-cAMP (3 × 10−3 M, 3 h). The inhibitory effect of the cytokine on testosterone secretion was not observed when Leydig cells were incubated with 22R-hydroxycholesterol (5 μg/ml, 2 h) or other steroid intermediates. Together, the present findings suggest that the antigonadotropin action of IL- 1α is predominantly exerted through a decrease in the availability of cholesterol substrate in the mitochondria for steroid hormone formation." @default.
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• W2155302012 date "1992-06-01" @default.
• W2155302012 modified "2023-10-17" @default.
• W2155302012 title "Interleukin-1α as a Potent Inhibitor of Gonadotropin Action in Porcine Leydig Cells: Site(s) of Action1" @default.
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• W2155302012 doi "https://doi.org/10.1095/biolreprod46.6.1119" @default.
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