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- W2155304845 endingPage "307" @default.
- W2155304845 startingPage "295" @default.
- W2155304845 abstract "In the ubiquitin network, a multitude of ubiquitin species is constantly decoded by ubiquitin-binding domains. To properly coordinate biological events, ubiquitylation depends on strict spatiotemporal regulation, which is achieved by compartmentalization, sequential series of ubiquitylation events and crosstalk with other post-translational modifications. In the past decade, the diversity of signals generated by the ubiquitin system has emerged as a dominant regulator of biological processes and propagation of information in the eukaryotic cell. A wealth of information has been gained about the crucial role of spatial and temporal regulation of ubiquitin species of different lengths and linkages in the nuclear factor-κB (NF-κB) pathway, endocytic trafficking, protein degradation and DNA repair. This spatiotemporal regulation is achieved through sophisticated mechanisms of compartmentalization and sequential series of ubiquitylation events and signal decoding, which control diverse biological processes not only in the cell but also during the development of tissues and entire organisms." @default.
- W2155304845 created "2016-06-24" @default.
- W2155304845 creator A5041954708 @default.
- W2155304845 creator A5069423243 @default.
- W2155304845 creator A5082730369 @default.
- W2155304845 date "2011-03-30" @default.
- W2155304845 modified "2023-10-10" @default.
- W2155304845 title "The spatial and temporal organization of ubiquitin networks" @default.
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