FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155306160> ?p ?o ?g. }

• W2155306160 endingPage "5" @default.
• W2155306160 startingPage "231" @default.
• W2155306160 abstract "Liver failure is still a significant clinical problem after transplantation surgery, tissue resections (the Pringle manoeuvre) and haemorrhagic shock. The restoration of blood flow to an ischaemic region leads to tissue injury at a greater rate than the original ischaemic insult, an event termed ischaemia-reperfusion injury (I/R). Despite advances in surgical techniques, I/R still poses a problem of clinical importance. In this research, we studied the effect of simvastatin pretreatment on liver and lung injury induced by hepatic I/R. Rats were subjected to 30 min of ischaemia followed by 24 h of reperfusion. Simvastatin (10 mg/kg) was administered orally from three days before the operation. After the reperfusion time, serum ALT, AST, LDH and TNF a levels were studied and liver and lung tissues were stained with haematoxylin and eosin and TUNEL to detect apoptotic cells. Serum aminotransferase activity and LDH and TNFalpha levels were increased markedly by hepatic I/R, and these were suppressed significantly by simvastatin. The tissue injury index and the number of apoptotic cells via TUNEL staining in the liver and lungs were higher in the I/R group than in the I/R + simvastatin group. These results suggest that simvastatin ameliorates I/R-induced liver and lung tissue damage by inhibiting the level of inflammation and the apoptotic pathways. Simvastatin administration may therefore provide protection against the adverse effects of I/R injury in liver transplantation." @default.
• W2155306160 created "2016-06-24" @default.
• W2155306160 creator A5023293630 @default.
• W2155306160 creator A5028026458 @default.
• W2155306160 creator A5036238542 @default.
• W2155306160 creator A5045682970 @default.
• W2155306160 creator A5071804288 @default.
• W2155306160 date "2008-11-01" @default.
• W2155306160 modified "2023-09-26" @default.
• W2155306160 title "Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats." @default.
• W2155306160 cites W1525331105 @default.
• W2155306160 cites W152983764 @default.
• W2155306160 cites W1970190570 @default.
• W2155306160 cites W1972952448 @default.
• W2155306160 cites W1974347337 @default.
• W2155306160 cites W1984312976 @default.
• W2155306160 cites W1991212363 @default.
• W2155306160 cites W2002426932 @default.
• W2155306160 cites W2010929029 @default.
• W2155306160 cites W2026609401 @default.
• W2155306160 cites W2033968552 @default.
• W2155306160 cites W2045063002 @default.
• W2155306160 cites W2050392973 @default.
• W2155306160 cites W2071124826 @default.
• W2155306160 cites W2077861214 @default.
• W2155306160 cites W2082928529 @default.
• W2155306160 cites W2086430306 @default.
• W2155306160 cites W2098894835 @default.
• W2155306160 cites W2105977216 @default.
• W2155306160 cites W2108116605 @default.
• W2155306160 cites W2113744229 @default.
• W2155306160 cites W2119523743 @default.
• W2155306160 cites W2121841947 @default.
• W2155306160 cites W2139128889 @default.
• W2155306160 cites W2139183408 @default.
• W2155306160 cites W2150683458 @default.
• W2155306160 cites W2156125238 @default.
• W2155306160 cites W2161821089 @default.
• W2155306160 cites W2164772129 @default.
• W2155306160 cites W2204312404 @default.
• W2155306160 cites W2471199165 @default.
• W2155306160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19085860" @default.
• W2155306160 hasPublicationYear "2008" @default.
• W2155306160 type Work @default.
• W2155306160 sameAs 2155306160 @default.
• W2155306160 citedByCount "8" @default.
• W2155306160 countsByYear W21553061602014 @default.
• W2155306160 countsByYear W21553061602015 @default.
• W2155306160 countsByYear W21553061602016 @default.
• W2155306160 crossrefType "journal-article" @default.
• W2155306160 hasAuthorship W2155306160A5023293630 @default.
• W2155306160 hasAuthorship W2155306160A5028026458 @default.
• W2155306160 hasAuthorship W2155306160A5036238542 @default.
• W2155306160 hasAuthorship W2155306160A5045682970 @default.
• W2155306160 hasAuthorship W2155306160A5071804288 @default.
• W2155306160 hasConcept C125473707 @default.
• W2155306160 hasConcept C126322002 @default.
• W2155306160 hasConcept C142724271 @default.
• W2155306160 hasConcept C196795494 @default.
• W2155306160 hasConcept C204232928 @default.
• W2155306160 hasConcept C2776329913 @default.
• W2155306160 hasConcept C2776637226 @default.
• W2155306160 hasConcept C2777714996 @default.
• W2155306160 hasConcept C2779609443 @default.
• W2155306160 hasConcept C2780114680 @default.
• W2155306160 hasConcept C2781448352 @default.
• W2155306160 hasConcept C2911091166 @default.
• W2155306160 hasConcept C503630168 @default.
• W2155306160 hasConcept C541997718 @default.
• W2155306160 hasConcept C71924100 @default.
• W2155306160 hasConcept C74864618 @default.
• W2155306160 hasConcept C98274493 @default.
• W2155306160 hasConceptScore W2155306160C125473707 @default.
• W2155306160 hasConceptScore W2155306160C126322002 @default.
• W2155306160 hasConceptScore W2155306160C142724271 @default.
• W2155306160 hasConceptScore W2155306160C196795494 @default.
• W2155306160 hasConceptScore W2155306160C204232928 @default.
• W2155306160 hasConceptScore W2155306160C2776329913 @default.
• W2155306160 hasConceptScore W2155306160C2776637226 @default.
• W2155306160 hasConceptScore W2155306160C2777714996 @default.
• W2155306160 hasConceptScore W2155306160C2779609443 @default.
• W2155306160 hasConceptScore W2155306160C2780114680 @default.
• W2155306160 hasConceptScore W2155306160C2781448352 @default.
• W2155306160 hasConceptScore W2155306160C2911091166 @default.
• W2155306160 hasConceptScore W2155306160C503630168 @default.
• W2155306160 hasConceptScore W2155306160C541997718 @default.
• W2155306160 hasConceptScore W2155306160C71924100 @default.
• W2155306160 hasConceptScore W2155306160C74864618 @default.
• W2155306160 hasConceptScore W2155306160C98274493 @default.
• W2155306160 hasIssue "4" @default.
• W2155306160 hasLocation W21553061601 @default.
• W2155306160 hasOpenAccess W2155306160 @default.
• W2155306160 hasPrimaryLocation W21553061601 @default.
• W2155306160 hasRelatedWork W1520748177 @default.
• W2155306160 hasRelatedWork W1966486150 @default.
• W2155306160 hasRelatedWork W1980572631 @default.
• W2155306160 hasRelatedWork W1988248190 @default.
• W2155306160 hasRelatedWork W1999260042 @default.

• next