FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155308488> ?p ?o ?g. }

• W2155308488 endingPage "1121" @default.
• W2155308488 startingPage "1106" @default.
• W2155308488 abstract "ABSTRACT Transforming growth factor β (TGF-β) superfamily members signal via complexes of activated Smads, comprising phosphorylated receptor-regulated Smads, such as Smad2 and Smad3, and Smad4. These complexes are recruited to DNA by specific transcription factors. The forkhead/winged-helix transcription factors, XFast-1/XFoxH1a and XFast-3/XFoxH1b, bind an activated Smad heterotrimer comprising two Smad2s and one Smad4. Here we identify a novel Smad2 interaction motif, the Fast/FoxH1 motif (FM), present in all known Fast/FoxH1 family members, N-terminal to the common Smad interaction motif (SIM). The FM is necessary and sufficient to bind active Smad2/Smad4 complexes. The FM differs from the SIM since it discriminates between Smad2 and Smad3, and moreover only binds phosphorylated Smad2 in the context of activated Smad complexes. It is the first Smad interaction motif with this property. Site-directed mutagenesis indicates that the binding site for the FM on a Smad2/Smad4 heterotrimer is a hydrophobic pocket that incorporates the Smad/Smad interface. We demonstrate that the presence of an FM and SIM in the Fast/FoxH1 proteins allows them to compete efficiently for activated Smad2/Smad4 complexes with transcription factors such as Mixer that only contain a SIM. This establishes a hierarchy of Smad-interacting transcription factors, determined by their affinity for active Smad complexes." @default.
• W2155308488 created "2016-06-24" @default.
• W2155308488 creator A5009170179 @default.
• W2155308488 creator A5015657268 @default.
• W2155308488 creator A5032952249 @default.
• W2155308488 creator A5035380866 @default.
• W2155308488 creator A5064893164 @default.
• W2155308488 creator A5065145095 @default.
• W2155308488 date "2004-02-01" @default.
• W2155308488 modified "2023-09-26" @default.
• W2155308488 title "Recognition of Phosphorylated-Smad2-Containing Complexes by a Novel Smad Interaction Motif" @default.
• W2155308488 cites W1515719112 @default.
• W2155308488 cites W1517566065 @default.
• W2155308488 cites W1596303197 @default.
• W2155308488 cites W1641035883 @default.
• W2155308488 cites W1662963035 @default.
• W2155308488 cites W1672956489 @default.
• W2155308488 cites W1840163537 @default.
• W2155308488 cites W1964036489 @default.
• W2155308488 cites W1968538228 @default.
• W2155308488 cites W1971991362 @default.
• W2155308488 cites W1978541292 @default.
• W2155308488 cites W1989307537 @default.
• W2155308488 cites W1999095939 @default.
• W2155308488 cites W2002195659 @default.
• W2155308488 cites W2006621251 @default.
• W2155308488 cites W2007044718 @default.
• W2155308488 cites W2007444505 @default.
• W2155308488 cites W2007620508 @default.
• W2155308488 cites W2007977302 @default.
• W2155308488 cites W2021263701 @default.
• W2155308488 cites W2023077752 @default.
• W2155308488 cites W2023574734 @default.
• W2155308488 cites W2027476051 @default.
• W2155308488 cites W2029667189 @default.
• W2155308488 cites W2036472425 @default.
• W2155308488 cites W2044164984 @default.
• W2155308488 cites W2047102823 @default.
• W2155308488 cites W2059437327 @default.
• W2155308488 cites W2070539534 @default.
• W2155308488 cites W2070760262 @default.
• W2155308488 cites W2071657576 @default.
• W2155308488 cites W2080239627 @default.
• W2155308488 cites W2085307258 @default.
• W2155308488 cites W2107942632 @default.
• W2155308488 cites W2109379227 @default.
• W2155308488 cites W2118446423 @default.
• W2155308488 cites W2122398263 @default.
• W2155308488 cites W2124207551 @default.
• W2155308488 cites W2129835280 @default.
• W2155308488 cites W2131767895 @default.
• W2155308488 cites W2140514445 @default.
• W2155308488 cites W2143714027 @default.
• W2155308488 cites W2146191765 @default.
• W2155308488 cites W2147769151 @default.
• W2155308488 cites W2158534713 @default.
• W2155308488 cites W2165857084 @default.
• W2155308488 doi "https://doi.org/10.1128/mcb.24.3.1106-1121.2004" @default.
• W2155308488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/321443" @default.
• W2155308488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14729957" @default.
• W2155308488 hasPublicationYear "2004" @default.
• W2155308488 type Work @default.
• W2155308488 sameAs 2155308488 @default.
• W2155308488 citedByCount "58" @default.
• W2155308488 countsByYear W21553084882013 @default.
• W2155308488 countsByYear W21553084882014 @default.
• W2155308488 countsByYear W21553084882015 @default.
• W2155308488 countsByYear W21553084882017 @default.
• W2155308488 countsByYear W21553084882018 @default.
• W2155308488 countsByYear W21553084882020 @default.
• W2155308488 countsByYear W21553084882021 @default.
• W2155308488 countsByYear W21553084882023 @default.
• W2155308488 crossrefType "journal-article" @default.
• W2155308488 hasAuthorship W2155308488A5009170179 @default.
• W2155308488 hasAuthorship W2155308488A5015657268 @default.
• W2155308488 hasAuthorship W2155308488A5032952249 @default.
• W2155308488 hasAuthorship W2155308488A5035380866 @default.
• W2155308488 hasAuthorship W2155308488A5064893164 @default.
• W2155308488 hasAuthorship W2155308488A5065145095 @default.
• W2155308488 hasBestOaLocation W21553084882 @default.
• W2155308488 hasConcept C11960822 @default.
• W2155308488 hasConcept C121332964 @default.
• W2155308488 hasConcept C24890656 @default.
• W2155308488 hasConcept C2781080636 @default.
• W2155308488 hasConcept C2909521502 @default.
• W2155308488 hasConcept C32276052 @default.
• W2155308488 hasConcept C54355233 @default.
• W2155308488 hasConcept C70721500 @default.
• W2155308488 hasConcept C86803240 @default.
• W2155308488 hasConcept C95444343 @default.
• W2155308488 hasConceptScore W2155308488C11960822 @default.
• W2155308488 hasConceptScore W2155308488C121332964 @default.
• W2155308488 hasConceptScore W2155308488C24890656 @default.
• W2155308488 hasConceptScore W2155308488C2781080636 @default.
• W2155308488 hasConceptScore W2155308488C2909521502 @default.
• W2155308488 hasConceptScore W2155308488C32276052 @default.
• W2155308488 hasConceptScore W2155308488C54355233 @default.
• W2155308488 hasConceptScore W2155308488C70721500 @default.

• next