FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155315053> ?p ?o ?g. }

• W2155315053 endingPage "3674" @default.
• W2155315053 startingPage "3664" @default.
• W2155315053 abstract "ABSTRACT The pharmacokinetics and safety of extended-interval dosing of prophylactic liposomal amphotericin B (L-AMB) in peripheral stem cell transplant recipients were evaluated. The patients received L-AMB daily at 1 mg/kg of body weight or weekly at 7.5 mg/kg or received L-AMB as a single dose (15 mg/kg). The buccal mucosal tissue concentrations of L-AMB were measured. Of the 24 patients enrolled, 5 withdrew after the initial dose due to an infusion-related reaction ( n = 2) or significant increases in the serum creatinine (Scr) levels ( n = 3). Weekly L-AMB dosing (7.5 mg/kg) produced mean plasma concentrations of >0.300 μg/ml for the first 7 days and >0.220 μg/ml for 7 days after the second dose. A single L-AMB dose (15 mg/kg) produced mean plasma concentrations of >0.491 μg/ml for at least 7 seven days. These concentrations are within the range of the MICs reported in the literature for susceptible strains of Candida and are at the lower limits of the MICs for Aspergillus spp. Extended-interval dosing produced buccal mucosal tissue concentrations well in excess of the MICs reported in the literature for susceptible strains of Candida and Aspergillus spp. Infusion-related reactions occurred in 24% of the patients. Baseline and end-of-study Scr, electrolyte (K + , Mg 2+ , PO 4 ), and serum transaminase levels were similar across the dosage groups. Five (31%) patients met the nephrotoxicity definition prior to completion of the study. Patients in the weekly or single-dose groups experienced nephrotoxicity significantly faster than the patients in the daily dosing cohort. A weekly L-AMB dose (7.5 mg/kg) or a single L-AMB dose (15 mg/kg) produced sufficient concentrations in plasma and highly vascular tissue to warrant further studies of the safety, efficacy, and practicality of the weekly prophylactic administration of L-AMB." @default.
• W2155315053 created "2016-06-24" @default.
• W2155315053 creator A5000393428 @default.
• W2155315053 creator A5005654803 @default.
• W2155315053 creator A5007152490 @default.
• W2155315053 creator A5055220639 @default.
• W2155315053 date "2009-09-01" @default.
• W2155315053 modified "2023-10-17" @default.
• W2155315053 title "Pharmacokinetics and Buccal Mucosal Concentrations of a 15 Milligram per Kilogram of Body Weight Total Dose of Liposomal Amphotericin B Administered as a Single Dose (15 mg/kg), Weekly Dose (7.5 mg/kg), or Daily Dose (1 mg/kg) in Peripheral Stem Cell Transplant Patients" @default.
• W2155315053 cites W1227548636 @default.
• W2155315053 cites W152943885 @default.
• W2155315053 cites W1967213408 @default.
• W2155315053 cites W1972629088 @default.
• W2155315053 cites W1972697824 @default.
• W2155315053 cites W1981312139 @default.
• W2155315053 cites W2000059357 @default.
• W2155315053 cites W2007960806 @default.
• W2155315053 cites W2012182421 @default.
• W2155315053 cites W2044937928 @default.
• W2155315053 cites W2052236634 @default.
• W2155315053 cites W2100849301 @default.
• W2155315053 cites W2102745741 @default.
• W2155315053 cites W2104240895 @default.
• W2155315053 cites W2109718032 @default.
• W2155315053 cites W2110782081 @default.
• W2155315053 cites W2115769369 @default.
• W2155315053 cites W2115915062 @default.
• W2155315053 cites W2118189687 @default.
• W2155315053 cites W2118957124 @default.
• W2155315053 cites W2130470240 @default.
• W2155315053 cites W2136787592 @default.
• W2155315053 cites W2139861683 @default.
• W2155315053 cites W2140450407 @default.
• W2155315053 cites W2142005104 @default.
• W2155315053 cites W2154039504 @default.
• W2155315053 cites W2160204310 @default.
• W2155315053 cites W2162801555 @default.
• W2155315053 cites W2172068234 @default.
• W2155315053 cites W2191567995 @default.
• W2155315053 cites W2411812256 @default.
• W2155315053 cites W63281979 @default.
• W2155315053 doi "https://doi.org/10.1128/aac.01448-08" @default.
• W2155315053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737893" @default.
• W2155315053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19546359" @default.
• W2155315053 hasPublicationYear "2009" @default.
• W2155315053 type Work @default.
• W2155315053 sameAs 2155315053 @default.
• W2155315053 citedByCount "32" @default.
• W2155315053 countsByYear W21553150532012 @default.
• W2155315053 countsByYear W21553150532013 @default.
• W2155315053 countsByYear W21553150532014 @default.
• W2155315053 countsByYear W21553150532015 @default.
• W2155315053 countsByYear W21553150532016 @default.
• W2155315053 countsByYear W21553150532017 @default.
• W2155315053 countsByYear W21553150532018 @default.
• W2155315053 countsByYear W21553150532019 @default.
• W2155315053 countsByYear W21553150532020 @default.
• W2155315053 countsByYear W21553150532021 @default.
• W2155315053 countsByYear W21553150532022 @default.
• W2155315053 crossrefType "journal-article" @default.
• W2155315053 hasAuthorship W2155315053A5000393428 @default.
• W2155315053 hasAuthorship W2155315053A5005654803 @default.
• W2155315053 hasAuthorship W2155315053A5007152490 @default.
• W2155315053 hasAuthorship W2155315053A5055220639 @default.
• W2155315053 hasBestOaLocation W21553150531 @default.
• W2155315053 hasConcept C112705442 @default.
• W2155315053 hasConcept C126189478 @default.
• W2155315053 hasConcept C126322002 @default.
• W2155315053 hasConcept C16005928 @default.
• W2155315053 hasConcept C195735259 @default.
• W2155315053 hasConcept C2777288759 @default.
• W2155315053 hasConcept C2779548794 @default.
• W2155315053 hasConcept C2779629538 @default.
• W2155315053 hasConcept C2780306776 @default.
• W2155315053 hasConcept C29730261 @default.
• W2155315053 hasConcept C71924100 @default.
• W2155315053 hasConcept C98274493 @default.
• W2155315053 hasConceptScore W2155315053C112705442 @default.
• W2155315053 hasConceptScore W2155315053C126189478 @default.
• W2155315053 hasConceptScore W2155315053C126322002 @default.
• W2155315053 hasConceptScore W2155315053C16005928 @default.
• W2155315053 hasConceptScore W2155315053C195735259 @default.
• W2155315053 hasConceptScore W2155315053C2777288759 @default.
• W2155315053 hasConceptScore W2155315053C2779548794 @default.
• W2155315053 hasConceptScore W2155315053C2779629538 @default.
• W2155315053 hasConceptScore W2155315053C2780306776 @default.
• W2155315053 hasConceptScore W2155315053C29730261 @default.
• W2155315053 hasConceptScore W2155315053C71924100 @default.
• W2155315053 hasConceptScore W2155315053C98274493 @default.
• W2155315053 hasIssue "9" @default.
• W2155315053 hasLocation W21553150531 @default.
• W2155315053 hasLocation W21553150532 @default.
• W2155315053 hasLocation W21553150533 @default.
• W2155315053 hasOpenAccess W2155315053 @default.
• W2155315053 hasPrimaryLocation W21553150531 @default.
• W2155315053 hasRelatedWork W2004325424 @default.
• W2155315053 hasRelatedWork W2049708617 @default.
• W2155315053 hasRelatedWork W2073125357 @default.

• next