FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155320427> ?p ?o ?g. }

• W2155320427 endingPage "119" @default.
• W2155320427 startingPage "118" @default.
• W2155320427 abstract "Background: Understanding the biologic milieu associated with differing symptom profiles in allogeneic HSCT survivors with cGVHD has the potential to clarify the pathogenesis of cGVHD activity and tissue damage, and may direct the development of new strategies to ameliorate symptoms and improve quality of life. Objective: To determine if differing cGVHD symptom profiles are associated with unique patterns of pro-inflammatory cytokine expression and markers of systemic immune activation. Methods: Plasma levels of sBAFF, IL-1β, IL-1 receptor antagonist, IL-6, soluble IL-6 receptor, soluble TNF-receptor II, MCP-1, and MIG were assayed by sandwich ELISA. Lymphocyte subset quantities were measured. Concurrently, the Lee Chronic GVHD Symptom Scale, a self-report measure of cGVHD symptoms, and clinical data were obtained. Data from 79 patients were analyzed using descriptive statistics, latent profile analysis, and multinomial logistic regression. Results: Three distinct symptom subgroups were identified through latent profile analysis: Group 1 (low on all symptoms), Group 2 (prominent oral, upper GI, and weight loss symptoms); and Group 3 (eye, muscle/joint, fatigue and mood symptoms). Multinomial logistic regression, controlling for age, length of time since transplant, cGVHD severity, intensity of immunosuppression and post-transplant lymphocyte reconstitution, revealed that IL-6, TNF-RII, MCP-1 and sBAFF levels significantly distinguished the three symptom subgroups.Tabled 1Odds Ratios and 95% Confidence Intervals for the Multinomial Logistic Regression of Symptom Latent Class Membership on Cytokines † Controlling for Age, Time Since Transplant, cGVHD Severity, Intensity of Current Immunosuppression and Absolute Lymphocyte Counts †Symptom Profile 1 (low on all symptoms) vs. Symptom Profile 2 (prominent oral/GI symptoms) OR (95% CI)Symptom Profile 1 (low on all symptoms) vs. Symptom Profile 3 (prominent eye, muscle/joint, fatigue and mood symptoms) OR (95% CI)Symptom Profile 2 (prominent oral/GI symptoms) vs. Symptom Profile 3 (prominent eye, muscle/joint, fatigue and mood symptoms) OR (95% CI)IL-1 β1.59 (0.30-8.45)0.92 (0.32-2.60)0.58 (0.10-3.32)IL-60.27 (0.09-0.79)∗p < .01 or p < .05, respectively, multinomial logistic regression.1.15 (0.52-2.52)4.26 (1.32-13.82)∗p < .01 or p < .05, respectively, multinomial logistic regression.IL-1 RA0.69 (0.22-2.14)0.55 (0.29-1.07)0.81 (0.26-2.48)sIL-6R0.50 (0.12-2.13)1.78 (0.54-5.90)3.53 (0.83-15.13)TNF-RII0.29 (0.04-2.42)0.28 (0.08-0.99)∗p < .01 or p < .05, respectively, multinomial logistic regression.0.95 (0.12-7.59)MCP-18.70 (1.46-51.66)∗p < .01 or p < .05, respectively, multinomial logistic regression.0.40 (0.11-1.40)0.05 (0.01-0.36)orMIG1.33 (0.73-2.44)1.02 (0.63-1.65)0.77 (0.42-1.39)sBAFF0.40 (0.13-1.30)1.86 (0.88-3.93)4.61 (1.39-15.31)or† values were log normal transformed prior to analysis∗∗ or∗ p < .01 or p < .05, respectively, multinomial logistic regression. Open table in a new tab Higher IL-6 levels significantly differentiated participants in Group 2 from those in Groups 1 and 3. Group 3 had higher TNF-RII compared to Group 1. Those with higher sBAFF levels were significantly more likely to be in Group 2, while those with higher MCP-1 levels were significantly more likely to be in Group 3. † values were log normal transformed prior to analysis Conclusion: Allogeneic HSCT survivors with differing cGVHD symptom profiles were distinguished by significantly different levels of IL-6, TNF-RII, MCP-1 and sBAFF. These data validate this new symptom grouping system based on the Lee Chronic GVHD Symptom Scale as a measure of cGVHD disease burden. IL-6, TNF-RII, MCP-1 and sBAFF appear to be important biomarkers that reflect specific cGVHD manifestations and merit further study." @default.
• W2155320427 created "2016-06-24" @default.
• W2155320427 creator A5002484217 @default.
• W2155320427 creator A5016587367 @default.
• W2155320427 creator A5031641594 @default.
• W2155320427 creator A5040821806 @default.
• W2155320427 creator A5043444899 @default.
• W2155320427 creator A5061749358 @default.
• W2155320427 creator A5062706815 @default.
• W2155320427 creator A5065897197 @default.
• W2155320427 creator A5066218992 @default.
• W2155320427 creator A5066746933 @default.
• W2155320427 creator A5072068693 @default.
• W2155320427 creator A5083416957 @default.
• W2155320427 creator A5083726514 @default.
• W2155320427 creator A5087278392 @default.
• W2155320427 date "2009-02-01" @default.
• W2155320427 modified "2023-09-28" @default.
• W2155320427 title "Plasma Cytokine Levels Distinguish Chronic Graft Versus Host Disease (cGVHD) Symptom Profile Groups" @default.
• W2155320427 doi "https://doi.org/10.1016/j.bbmt.2008.12.365" @default.
• W2155320427 hasPublicationYear "2009" @default.
• W2155320427 type Work @default.
• W2155320427 sameAs 2155320427 @default.
• W2155320427 citedByCount "0" @default.
• W2155320427 crossrefType "journal-article" @default.
• W2155320427 hasAuthorship W2155320427A5002484217 @default.
• W2155320427 hasAuthorship W2155320427A5016587367 @default.
• W2155320427 hasAuthorship W2155320427A5031641594 @default.
• W2155320427 hasAuthorship W2155320427A5040821806 @default.
• W2155320427 hasAuthorship W2155320427A5043444899 @default.
• W2155320427 hasAuthorship W2155320427A5061749358 @default.
• W2155320427 hasAuthorship W2155320427A5062706815 @default.
• W2155320427 hasAuthorship W2155320427A5065897197 @default.
• W2155320427 hasAuthorship W2155320427A5066218992 @default.
• W2155320427 hasAuthorship W2155320427A5066746933 @default.
• W2155320427 hasAuthorship W2155320427A5072068693 @default.
• W2155320427 hasAuthorship W2155320427A5083416957 @default.
• W2155320427 hasAuthorship W2155320427A5083726514 @default.
• W2155320427 hasAuthorship W2155320427A5087278392 @default.
• W2155320427 hasConcept C117568660 @default.
• W2155320427 hasConcept C119857082 @default.
• W2155320427 hasConcept C126322002 @default.
• W2155320427 hasConcept C151956035 @default.
• W2155320427 hasConcept C203014093 @default.
• W2155320427 hasConcept C2777761686 @default.
• W2155320427 hasConcept C2779134260 @default.
• W2155320427 hasConcept C2779972918 @default.
• W2155320427 hasConcept C2780252810 @default.
• W2155320427 hasConcept C2780942790 @default.
• W2155320427 hasConcept C41008148 @default.
• W2155320427 hasConcept C71924100 @default.
• W2155320427 hasConcept C90924648 @default.
• W2155320427 hasConceptScore W2155320427C117568660 @default.
• W2155320427 hasConceptScore W2155320427C119857082 @default.
• W2155320427 hasConceptScore W2155320427C126322002 @default.
• W2155320427 hasConceptScore W2155320427C151956035 @default.
• W2155320427 hasConceptScore W2155320427C203014093 @default.
• W2155320427 hasConceptScore W2155320427C2777761686 @default.
• W2155320427 hasConceptScore W2155320427C2779134260 @default.
• W2155320427 hasConceptScore W2155320427C2779972918 @default.
• W2155320427 hasConceptScore W2155320427C2780252810 @default.
• W2155320427 hasConceptScore W2155320427C2780942790 @default.
• W2155320427 hasConceptScore W2155320427C41008148 @default.
• W2155320427 hasConceptScore W2155320427C71924100 @default.
• W2155320427 hasConceptScore W2155320427C90924648 @default.
• W2155320427 hasIssue "2" @default.
• W2155320427 hasLocation W21553204271 @default.
• W2155320427 hasOpenAccess W2155320427 @default.
• W2155320427 hasPrimaryLocation W21553204271 @default.
• W2155320427 hasRelatedWork W117993291 @default.
• W2155320427 hasRelatedWork W1972654344 @default.
• W2155320427 hasRelatedWork W2014965697 @default.
• W2155320427 hasRelatedWork W2028427620 @default.
• W2155320427 hasRelatedWork W204558573 @default.
• W2155320427 hasRelatedWork W2067687598 @default.
• W2155320427 hasRelatedWork W2328139916 @default.
• W2155320427 hasRelatedWork W2431272492 @default.
• W2155320427 hasRelatedWork W2588107243 @default.
• W2155320427 hasRelatedWork W3197848954 @default.
• W2155320427 hasVolume "15" @default.
• W2155320427 isParatext "false" @default.
• W2155320427 isRetracted "false" @default.
• W2155320427 magId "2155320427" @default.
• W2155320427 workType "article" @default.