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• W2155320456 endingPage "3100" @default.
• W2155320456 startingPage "3093" @default.
• W2155320456 abstract "Abstract We studied the effects of serotonin (5‐HT) on hippocampal CA1 pyramidal neurons. In current‐clamp mode, 5‐HT induced a hyperpolarization and reduction of excitability due to the opening of inward rectifier K + channels, followed by a late depolarization and partial restoration of excitability. These two components could be dissociated, as in the presence of BaCl 2 to block K + channels, 5‐HT induced a depolarization accompanied by a reduction of membrane resistance, whereas in the presence of ZD 7288 [4‐(N‐ethyl‐N‐phenylamino)‐1,2‐dimethyl‐6‐(methylamino) pyrimidinium chloride], a selective blocker of the hyperpolarization‐activated cation current (I h ), 5‐HT only hyperpolarized neurons. We then studied the action of 5‐HT on I h in voltage‐clamp conditions. 5‐HT increased I h at −90 mV by 29.1 ± 2.9% and decreased the time constant of activation by 20.1 ± 1.7% (n = 16), suggesting a shift in the voltage dependence of the current towards more positive potentials; however, the fully activated current measured at −140 mV also increased (by 14.1 ± 1.7%, n = 14); this increase was blocked by ZD 7288, implying an effect of 5‐HT on the maximal conductance of I h . Both the shift of activation curve and the increase in maximal conductance were confirmed by data obtained with ramp protocols. Perfusion with the membrane‐permeable analogue of cAMP, 8‐bromoadenosine 3′5′‐cyclic monophosphate (8‐Br‐cAMP), increased I h both at −90 and −140 mV, although the changes induced were smaller than those due to 5‐HT. Our data indicate that 5‐HT modulates I h by shifting its activation curve to more positive voltages and by increasing its maximal conductance, and that this action is likely to contribute to the 5‐HT modulation of excitability of CA1 cells." @default.
• W2155320456 created "2016-06-24" @default.
• W2155320456 creator A5016926365 @default.
• W2155320456 creator A5055939400 @default.
• W2155320456 date "1999-09-01" @default.
• W2155320456 modified "2023-10-14" @default.
• W2155320456 title "Action of serotonin on the hyperpolarization‐activated cation current (I_h) in rat CA1 hippocampal neurons" @default.
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• W2155320456 doi "https://doi.org/10.1046/j.1460-9568.1999.00728.x" @default.
• W2155320456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10510173" @default.
• W2155320456 hasPublicationYear "1999" @default.
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