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• W2155331329 startingPage "2046" @default.
• W2155331329 abstract "Relationships between adherence to protease inhibitor (PI)-based therapy and resistance development have not been fully characterized.We conducted a double-blind, randomized, controlled study of lopinavir/ritonavir versus nelfinavir, each administered with stavudine and lamivudine, in 653 antiretroviral-naive, human immunodeficiency virus (HIV)-1-infected patients. Relationships between adherence and probability of resistance development were evaluated by local linear regression or logistic regression.A higher risk of detectable HIV-1 RNA loads after week 24 was associated with lower adherence (odds ratio [OR], 1.08 per 1% decrease in adherence [95% confidence interval {CI}, 1.05-1.10]; P<.001) and nelfinavir use (OR, 2.4 vs. lopinavir/ritonavir [95% CI, 1.6-3.6]; P<.001). Among all nelfinavir-treated patients, a bell-shaped relationship between adherence and the risk of nelfinavir resistance was observed, with a maximum probability of 20% at 85%-90% adherence. No lopinavir resistance was observed. A bell-shaped relationship was also observed for the probability of lamivudine resistance, with a maximum probability of 50% at 75%-80% adherence to nelfinavir and of 15% at 80%-85% adherence to lopinavir/ritonavir.Bell-shaped relationships between adherence and resistance were observed. Irrespective of adherence level, the risk of detectable HIV-1 RNA loads or of PI or lamivudine resistance was significantly higher in nelfinavir-treated patients than in lopinavir/ritonavir-treated patients." @default.
• W2155331329 created "2016-06-24" @default.
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• W2155331329 date "2005-06-15" @default.
• W2155331329 modified "2023-10-16" @default.
• W2155331329 title "Relationship between Adherence and the Development of Resistance in Antiretroviral‐Naive, HIV‐1–Infected Patients Receiving Lopinavir/Ritonavir or Nelfinavir" @default.
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• W2155331329 doi "https://doi.org/10.1086/430387" @default.
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