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• W2155332509 startingPage "146" @default.
• W2155332509 abstract "Objective: The most commonly reported side effects of methylphenidate, which is generally used for attention deficit hyperactivity disorder, are loss of appetite, decrease of body weight and initial growth retardation. Ghrelin, which is dominantly released by the stomach, promotes feeding, decreases energy expenditure and locomotor activity, enhances weight gain and fat mass deposition and also effects gastrointestinal motility. Ghrelin may be related to the metabolic and anorexigenic effects of methylphenidate in children. The aim of this study was to investigate methylphenidate's effect on fasting serum active ghrelin levels in prepubertal children with attention deficit hyperactivity disorder. We expected to find a difference between pre- and post-treatment ghrelin levels with 18 mg/day methylphenidate administered via an osmotic-controlled release oral delivery system in prepubertal boys.Methods: Thirty-three boys with attention deficit hyperactivity disorder between the ages of 6–12 were recruited for this investigation. In addition to ghrelin levels, other laboratory findings, body mass index, body mass index percentiles, body weight-height measures and attention deficit-hyperactivity disorder symptom severity findings were analyzed before and after the 60 days of methylphenidate treatment.Results: We could not find a significant alteration in serum active ghrelin levels with methylphenidate. Methylphenidate improved core inattention, hyperactivity and impulsivity symptoms of attention deficit hyperactivity disorder with no significant alteration in height, body weight and body mass index, without serious side effects.Conclusion: This is the first study which directly aims to determine methylphenidate's effect on serum active ghrelin levels. Further research with higher methylphenidate doses and/or other stimulants such as atomoxetine and amphetamine should be done as ghrelin is also associated with obesity, alcohol and drug addiction and reward system pathologies, which are also closely related to attention deficit hyperactivity disorder." @default.
• W2155332509 created "2016-06-24" @default.
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• W2155332509 date "2014-06-01" @default.
• W2155332509 modified "2023-10-18" @default.
• W2155332509 title "Effects of Long Acting Methylphenidate on Ghrelin Levels in Male Children with Attention Deficit Hyperactivity Disorder: An Open Label Trial" @default.
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• W2155332509 doi "https://doi.org/10.5455/bcp.20130708042604" @default.
• W2155332509 hasPublicationYear "2014" @default.
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