FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155335963> ?p ?o ?g. }

• W2155335963 endingPage "5287" @default.
• W2155335963 startingPage "5281" @default.
• W2155335963 abstract "Although mitochondrial electron transport is a validated target of the antimalarial drug atovaquone, the molecular details underlying parasite demise are unclear. We have shown that a critical function of mitochondrial electron transport in blood-stage Plasmodium falciparum is to support pyrimidine biosynthesis. Here, we explore the effects of atovaquone, alone and in combination with proguanil, on P. falciparum viability. Our results suggest that the effects of inhibition depend upon the erythrocytic stage of the parasites and the duration of exposure. Ring- and schizont-stage parasites are most resilient to drug treatment and can survive for 48 h, with a fraction remaining viable even after 96 h. Survival of parasites does not appear to require nutrient uptake. Thus, intraerythrocytic parasites with inhibited mitochondrial electron transport and collapsed mitochondrial membrane potential do not undergo apoptosis but enter an apparent static state. These results have significant implications for desirable properties of antimalarials under development that target mitochondrial functions." @default.
• W2155335963 created "2016-06-24" @default.
• W2155335963 creator A5004953286 @default.
• W2155335963 creator A5050162568 @default.
• W2155335963 creator A5052238251 @default.
• W2155335963 date "2010-12-01" @default.
• W2155335963 modified "2023-09-27" @default.
• W2155335963 title "Mitochondrial Electron Transport Inhibition and Viability of Intraerythrocytic <i>Plasmodium falciparum</i>" @default.
• W2155335963 cites W1586796410 @default.
• W2155335963 cites W1935016814 @default.
• W2155335963 cites W1969503178 @default.
• W2155335963 cites W1976977157 @default.
• W2155335963 cites W1990805655 @default.
• W2155335963 cites W1992637245 @default.
• W2155335963 cites W1992733039 @default.
• W2155335963 cites W1999692874 @default.
• W2155335963 cites W2001276105 @default.
• W2155335963 cites W2007561244 @default.
• W2155335963 cites W2017288076 @default.
• W2155335963 cites W2023160008 @default.
• W2155335963 cites W2025605230 @default.
• W2155335963 cites W2037573325 @default.
• W2155335963 cites W2046199004 @default.
• W2155335963 cites W2055792051 @default.
• W2155335963 cites W2058070876 @default.
• W2155335963 cites W2063725332 @default.
• W2155335963 cites W2075055296 @default.
• W2155335963 cites W2085832074 @default.
• W2155335963 cites W2088624570 @default.
• W2155335963 cites W2104243533 @default.
• W2155335963 cites W2105668259 @default.
• W2155335963 cites W2112941164 @default.
• W2155335963 cites W2129502763 @default.
• W2155335963 cites W2129539565 @default.
• W2155335963 cites W2136690044 @default.
• W2155335963 cites W2140720035 @default.
• W2155335963 doi "https://doi.org/10.1128/aac.00937-10" @default.
• W2155335963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2981233" @default.
• W2155335963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20855748" @default.
• W2155335963 hasPublicationYear "2010" @default.
• W2155335963 type Work @default.
• W2155335963 sameAs 2155335963 @default.
• W2155335963 citedByCount "54" @default.
• W2155335963 countsByYear W21553359632012 @default.
• W2155335963 countsByYear W21553359632013 @default.
• W2155335963 countsByYear W21553359632014 @default.
• W2155335963 countsByYear W21553359632015 @default.
• W2155335963 countsByYear W21553359632016 @default.
• W2155335963 countsByYear W21553359632017 @default.
• W2155335963 countsByYear W21553359632018 @default.
• W2155335963 countsByYear W21553359632019 @default.
• W2155335963 countsByYear W21553359632020 @default.
• W2155335963 countsByYear W21553359632021 @default.
• W2155335963 countsByYear W21553359632022 @default.
• W2155335963 countsByYear W21553359632023 @default.
• W2155335963 crossrefType "journal-article" @default.
• W2155335963 hasAuthorship W2155335963A5004953286 @default.
• W2155335963 hasAuthorship W2155335963A5050162568 @default.
• W2155335963 hasAuthorship W2155335963A5052238251 @default.
• W2155335963 hasBestOaLocation W21553359631 @default.
• W2155335963 hasConcept C104317684 @default.
• W2155335963 hasConcept C136764020 @default.
• W2155335963 hasConcept C203014093 @default.
• W2155335963 hasConcept C24586158 @default.
• W2155335963 hasConcept C24840226 @default.
• W2155335963 hasConcept C2778048844 @default.
• W2155335963 hasConcept C2778371730 @default.
• W2155335963 hasConcept C2778675580 @default.
• W2155335963 hasConcept C2779124865 @default.
• W2155335963 hasConcept C28859421 @default.
• W2155335963 hasConcept C41008148 @default.
• W2155335963 hasConcept C55493867 @default.
• W2155335963 hasConcept C71928629 @default.
• W2155335963 hasConcept C75385678 @default.
• W2155335963 hasConcept C86803240 @default.
• W2155335963 hasConcept C95444343 @default.
• W2155335963 hasConceptScore W2155335963C104317684 @default.
• W2155335963 hasConceptScore W2155335963C136764020 @default.
• W2155335963 hasConceptScore W2155335963C203014093 @default.
• W2155335963 hasConceptScore W2155335963C24586158 @default.
• W2155335963 hasConceptScore W2155335963C24840226 @default.
• W2155335963 hasConceptScore W2155335963C2778048844 @default.
• W2155335963 hasConceptScore W2155335963C2778371730 @default.
• W2155335963 hasConceptScore W2155335963C2778675580 @default.
• W2155335963 hasConceptScore W2155335963C2779124865 @default.
• W2155335963 hasConceptScore W2155335963C28859421 @default.
• W2155335963 hasConceptScore W2155335963C41008148 @default.
• W2155335963 hasConceptScore W2155335963C55493867 @default.
• W2155335963 hasConceptScore W2155335963C71928629 @default.
• W2155335963 hasConceptScore W2155335963C75385678 @default.
• W2155335963 hasConceptScore W2155335963C86803240 @default.
• W2155335963 hasConceptScore W2155335963C95444343 @default.
• W2155335963 hasIssue "12" @default.
• W2155335963 hasLocation W21553359631 @default.
• W2155335963 hasLocation W21553359632 @default.
• W2155335963 hasLocation W21553359633 @default.
• W2155335963 hasLocation W21553359634 @default.
• W2155335963 hasOpenAccess W2155335963 @default.

• next