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- W2155342128 abstract "Abstract The crowded environments inside cells can have significant effects on the folding stability and other biophysical properties of proteins. In this study on how macromolecular crowding affects protein folding, we took a significant step toward realistically mimicking intracellular environments by using a mixture of two crowding agents, Ficoll and dextran. We found that the mixed crowding exerts a greater stabilizing effect than the sum of the two individual crowding agents. Therefore, the composition of crowders, not just the total concentration, has a significant influence on the effects of crowding on protein folding. Since the composition of intracellular macromolecules varies within the lifetime of a cell, our finding may provide an explanation for age being an important risk factor for protein aggregation‐related diseases such as Alzheimer's disease and Parkinson's disease. Proteins 2009. © 2009 Wiley‐Liss, Inc." @default.
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- W2155342128 date "2009-04-30" @default.
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- W2155342128 title "Nonadditive effects of mixed crowding on protein stability" @default.
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- W2155342128 doi "https://doi.org/10.1002/prot.22425" @default.
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