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• W2155349733 abstract "Most models of genome evolution concern either genetic sequences, gene content or gene order. They sometimes integrate two of the three levels, but rarely the three of them. Probabilistic models of gene order evolution usually have to assume constant gene content or adopt a presence/absence coding of gene neighborhoods which is blind to complex events modifying gene content.We propose a probabilistic evolutionary model for gene neighborhoods, allowing genes to be inserted, duplicated or lost. It uses reconciled phylogenies, which integrate sequence and gene content evolution. We are then able to optimize parameters such as phylogeny branch lengths, or probabilistic laws depicting the diversity of susceptibility of syntenic regions to rearrangements. We reconstruct a structure for ancestral genomes by optimizing a likelihood, keeping track of all evolutionary events at the level of gene content and gene synteny. Ancestral syntenies are associated with a probability of presence." @default.
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• W2155349733 date "2015-10-02" @default.
• W2155349733 modified "2023-10-18" @default.
• W2155349733 title "Probabilistic modeling of the evolution of gene synteny within reconciled phylogenies" @default.
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• W2155349733 doi "https://doi.org/10.1186/1471-2105-16-s14-s5" @default.
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