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• W2155352579 startingPage "17275" @default.
• W2155352579 abstract "A novel series of 4-aryl-3-cyano-2-(3-hydroxyphenyl)-6-morpholino-pyridines have been designed as potential phosphatidylinositol-3-kinase (PI3K) inhibitors. The compounds have been synthesized using the Guareschi reaction to prepare the key 4-aryl-3-cyano-2,6-dihydroxypyridine intermediate. A different selectivity according to the nature of the aryl group has been observed. Compound 9b is a selective inhibitor against the PI3Kα isoform, maintaining a good inhibitory activity. Docking studies were also performed in order to rationalize its profile of selectivity." @default.
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• W2155352579 date "2015-09-18" @default.
• W2155352579 modified "2023-10-13" @default.
• W2155352579 title "The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors" @default.
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• W2155352579 doi "https://doi.org/10.3390/molecules200917275" @default.
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• W2155352579 hasPublicationYear "2015" @default.
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