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• W2155360602 abstract "In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a-i and 6a-g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen species (ROS) level, suggesting that it may be a potent antitumor agent. In addition, compound 6g with very low cytotoxicity, demonstrated excellent fluorescence properties, which could be used as an effective fluorescence probe for biological imaging." @default.
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• W2155360602 date "2015-10-13" @default.
• W2155360602 modified "2023-09-27" @default.
• W2155360602 title "Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives" @default.
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• W2155360602 doi "https://doi.org/10.3390/molecules201018565" @default.
• W2155360602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332379" @default.
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