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• W2155362972 endingPage "1992" @default.
• W2155362972 startingPage "1979" @default.
• W2155362972 abstract "Abstract Bloom Syndrome, a rare human disorder characterized by genomic instability and predisposition to cancer, is caused by mutation of BLM, which encodes a RecQ-family DNA helicase. The Drosophila melanogaster ortholog of BLM, DmBlm, is encoded by mus309. Mutations in mus309 cause hypersensitivity to DNA-damaging agents, female sterility, and defects in repairing double-strand breaks (DSBs). To better understand these phenotypes, we isolated novel mus309 alleles. Mutations that delete the N terminus of DmBlm, but not the helicase domain, have DSB repair defects as severe as those caused by null mutations. We found that female sterility is due to a requirement for DmBlm in early embryonic cell cycles; embryos lacking maternally derived DmBlm have anaphase bridges and other mitotic defects. These defects were less severe for the N-terminal deletion alleles, so we used one of these mutations to assay meiotic recombination. Crossovers were decreased to about half the normal rate, and the remaining crossovers were evenly distributed along the chromosome. We also found that spontaneous mitotic crossovers are increased by several orders of magnitude in mus309 mutants. These results demonstrate that DmBlm functions in multiple cellular contexts to promote genome stability." @default.
• W2155362972 created "2016-06-24" @default.
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• W2155362972 creator A5089054445 @default.
• W2155362972 date "2007-08-01" @default.
• W2155362972 modified "2023-10-18" @default.
• W2155362972 title "Multiple Functions of Drosophila BLM Helicase in Maintenance of Genome Stability" @default.
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• W2155362972 doi "https://doi.org/10.1534/genetics.106.070052" @default.
• W2155362972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1950607" @default.
• W2155362972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17507683" @default.
• W2155362972 hasPublicationYear "2007" @default.
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