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- W2155363902 abstract "The epicardium serves as a source of growth factors that regulate myocardial proliferation and as a source of epicardial-derived cells (EPDC), which give rise to interstitial cardiac fibroblasts and perivascular cells. These progenitors populate the compact myocardium to become part of the mature coronary vasculature and fibrous skeleton of the heart. Little is known about the mechanisms that regulate EPDC migration into the myocardium or the functions carried out by these cells once they enter the myocardium. However, it has been proposed that cardiac fibroblasts are important for growth of the heart during late gestation and are a source of homeostatic factors in the adult. Here, we identify a myocardial to epicardial fibroblast growth factor (FGF) signal, mediated by FGF10 and FGFR2b, that is essential for movement of cardiac fibroblasts into the compact myocardium. Inactivation of this signaling pathway results in fewer epicardial derived cells within the compact myocardium, decreased myocardial proliferation and a resulting smaller thin-walled heart." @default.
- W2155363902 created "2016-06-24" @default.
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- W2155363902 creator A5007118272 @default.
- W2155363902 creator A5009783988 @default.
- W2155363902 creator A5062596447 @default.
- W2155363902 date "2011-08-01" @default.
- W2155363902 modified "2023-09-30" @default.
- W2155363902 title "FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium" @default.
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- W2155363902 doi "https://doi.org/10.1242/dev.064410" @default.
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