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- W2155365964 abstract "Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases, clinically characterised by cognitive decline, paralleled by severe damage to the central nervous system. Prion diseases have attracted a broad interest because of their unique mechanisms of replication and propagation; however, the underlying pathogenic mechanisms are still highly speculative. In this review, current knowledge about the pathogenesis of prion diseases in the CNS will be highlighted and the most revealing animal models will be discussed, with future perspectives to address immediate questions about the pathogenesis." @default.
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- W2155365964 date "2003-06-01" @default.
- W2155365964 modified "2023-09-25" @default.
- W2155365964 title "CNS pathogenesis of prion diseases" @default.
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- W2155365964 doi "https://doi.org/10.1093/bmb/66.1.131" @default.
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