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• W2155366909 startingPage "410" @default.
• W2155366909 abstract "The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins and G protein-coupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. The aim of this review is to summarize our current knowledge on some recently identified functional paradigms and signaling networks that might help to elucidate the functional diversity of the α(1)-AR subtypes in various organs." @default.
• W2155366909 created "2016-06-24" @default.
• W2155366909 creator A5071543585 @default.
• W2155366909 date "2010-10-18" @default.
• W2155366909 modified "2023-10-18" @default.
• W2155366909 title "The α₁-adrenergic receptors: diversity of signaling networks and regulation" @default.
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• W2155366909 doi "https://doi.org/10.3109/10799893.2010.518152" @default.
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