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- W2155369995 abstract "The catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB is known to proceed through the intermediate formation of hydroquinone. Here, we provide evidence that hydroquinone is further degraded through 4-hydroxymuconic semialdehyde and maleylacetate to beta-ketoadipate. The P. fluorescens ACB genes involved in 4-hydroxyacetophenone utilization were cloned and characterized. Sequence analysis of a 15-kb DNA fragment showed the presence of 14 open reading frames containing a gene cluster (hapCDEFGHIBA) of which at least four encoded enzymes are involved in 4-hydroxyacetophenone degradation: 4-hydroxyacetophenone monooxygenase (hapA), 4-hydroxyphenyl acetate hydrolase (hapB), 4-hydroxymuconic semialdehyde dehydrogenase (hapE), and maleylacetate reductase (hapF). In between hapF and hapB, three genes encoding a putative intradiol dioxygenase (hapG), a protein of the Yci1 family (hapH), and a [2Fe-2S] ferredoxin (hapI) were found. Downstream of the hap genes, five open reading frames are situated encoding three putative regulatory proteins (orf10, orf12, and orf13) and two proteins possibly involved in a membrane efflux pump (orf11 and orf14). Upstream of hapE, two genes (hapC and hapD) were present that showed weak similarity with several iron(II)-dependent extradiol dioxygenases. Based on these findings and additional biochemical evidence, it is proposed that the hapC and hapD gene products are involved in the ring cleavage of hydroquinone." @default.
- W2155369995 created "2016-06-24" @default.
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- W2155369995 creator A5083203989 @default.
- W2155369995 date "2008-08-01" @default.
- W2155369995 modified "2023-10-10" @default.
- W2155369995 title "Elucidation of the 4-Hydroxyacetophenone Catabolic Pathway in <i>Pseudomonas fluorescens</i> ACB" @default.
- W2155369995 cites W110720659 @default.
- W2155369995 cites W1254562219 @default.
- W2155369995 cites W1483731027 @default.
- W2155369995 cites W1484081994 @default.
- W2155369995 cites W1492640974 @default.
- W2155369995 cites W1514812733 @default.
- W2155369995 cites W1541663637 @default.
- W2155369995 cites W1547243152 @default.
- W2155369995 cites W1548521778 @default.
- W2155369995 cites W1574688274 @default.
- W2155369995 cites W1583218826 @default.
- W2155369995 cites W1587972926 @default.
- W2155369995 cites W1617250722 @default.
- W2155369995 cites W1625660792 @default.
- W2155369995 cites W1632346421 @default.
- W2155369995 cites W1772451113 @default.
- W2155369995 cites W1818468124 @default.
- W2155369995 cites W1863065468 @default.
- W2155369995 cites W1874519088 @default.
- W2155369995 cites W1877248188 @default.
- W2155369995 cites W1877788388 @default.
- W2155369995 cites W1969755615 @default.
- W2155369995 cites W1969962374 @default.
- W2155369995 cites W1971711708 @default.
- W2155369995 cites W1977258613 @default.
- W2155369995 cites W1977471578 @default.
- W2155369995 cites W1977905617 @default.
- W2155369995 cites W1978654607 @default.
- W2155369995 cites W1991908994 @default.
- W2155369995 cites W1997100196 @default.
- W2155369995 cites W1999796020 @default.
- W2155369995 cites W2001639631 @default.
- W2155369995 cites W2003318140 @default.
- W2155369995 cites W2009570597 @default.
- W2155369995 cites W2009793833 @default.
- W2155369995 cites W2010984666 @default.
- W2155369995 cites W2020022685 @default.
- W2155369995 cites W2024438005 @default.
- W2155369995 cites W2029508736 @default.
- W2155369995 cites W2033330355 @default.
- W2155369995 cites W2036498079 @default.
- W2155369995 cites W2042929656 @default.
- W2155369995 cites W2043421474 @default.
- W2155369995 cites W2049212913 @default.
- W2155369995 cites W2050997831 @default.
- W2155369995 cites W2053047911 @default.
- W2155369995 cites W2056054012 @default.
- W2155369995 cites W2058325166 @default.
- W2155369995 cites W2059269003 @default.
- W2155369995 cites W2061289916 @default.
- W2155369995 cites W2065835299 @default.
- W2155369995 cites W2067409463 @default.
- W2155369995 cites W2069031486 @default.
- W2155369995 cites W2069402529 @default.
- W2155369995 cites W2078754157 @default.
- W2155369995 cites W2087769436 @default.
- W2155369995 cites W2096066369 @default.
- W2155369995 cites W2097110709 @default.
- W2155369995 cites W2097563545 @default.
- W2155369995 cites W2098380659 @default.
- W2155369995 cites W2101207435 @default.
- W2155369995 cites W2104051423 @default.
- W2155369995 cites W2106882534 @default.
- W2155369995 cites W2111095768 @default.
- W2155369995 cites W2111929724 @default.
- W2155369995 cites W2112069812 @default.
- W2155369995 cites W2112910900 @default.
- W2155369995 cites W2114878375 @default.
- W2155369995 cites W2118672046 @default.
- W2155369995 cites W2124649383 @default.
- W2155369995 cites W2125173421 @default.
- W2155369995 cites W2128022325 @default.
- W2155369995 cites W2129311744 @default.
- W2155369995 cites W2130913111 @default.
- W2155369995 cites W2131591496 @default.
- W2155369995 cites W2131904858 @default.
- W2155369995 cites W2151107150 @default.
- W2155369995 cites W2155205527 @default.
- W2155369995 cites W2155407291 @default.
- W2155369995 cites W2156666818 @default.
- W2155369995 cites W2168419042 @default.
- W2155369995 cites W2170824150 @default.
- W2155369995 cites W2342610670 @default.
- W2155369995 cites W2410632833 @default.
- W2155369995 cites W3036081194 @default.
- W2155369995 cites W4244755686 @default.