FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155373039> ?p ?o ?g. }

• W2155373039 endingPage "976" @default.
• W2155373039 startingPage "969" @default.
• W2155373039 abstract "Oxytocin (OT) is produced by granulosa cells (GCs) of pre-ovulatory ovarian follicles and the corpus luteum (CL) in some mammalian species. Actions of OT in the ovary have been linked to luteinization, steroidogenesis and luteolysis. Human IVF-derived (h)GCs possess a functional OT receptor (OTR), linked to elevation of intracellular Ca(2+), but molecular identity of the receptor for OT in human granulosa cells (hGCs) and down-stream consequences are not known.RT-PCR, sequencing and immunocytochemistry identified the genuine OTR in hGCs. OT (10 nM-10 microM) induced elevations of intracellular Ca(2+) levels (Fluo-4 measurements), which were blocked by tocinoic acid (TA; 50 microM, a selective OTR-antagonist). Down-stream effects of OTR-activation include a concentration dependent decrease in cell viability/metabolism, manifested by reduced ATP-levels, increased caspase3/7-activity (P < 0.05) and electron microscopical signs of cellular regression. TA blocked all of these changes. Immunoreactive OTR was found in the CL and GCs of large and, surprisingly, also small pre-antral follicles of the human ovary. Immunoreactive OTR in the rhesus monkey ovary was detected in primordial and growing primary follicles in the infantile ovary and in follicles at all stages of development in the adult ovary, as well as the CL: these results were corroborated by RT-PCR analysis of GCs excised by laser capture microdissection.Our study identifies genuine OTRs in human and rhesus monkey GCs. Activation by high levels of OT leads to cellular regression in hGCs. As GCs of small follicles also express OTRs, OT may have as yet unknown functions in follicular development." @default.
• W2155373039 created "2016-06-24" @default.
• W2155373039 creator A5011093399 @default.
• W2155373039 creator A5012039592 @default.
• W2155373039 creator A5015099322 @default.
• W2155373039 creator A5020505378 @default.
• W2155373039 creator A5023969533 @default.
• W2155373039 creator A5047403775 @default.
• W2155373039 creator A5070758515 @default.
• W2155373039 creator A5071942655 @default.
• W2155373039 date "2010-01-23" @default.
• W2155373039 modified "2023-10-05" @default.
• W2155373039 title "Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells" @default.
• W2155373039 cites W1589415602 @default.
• W2155373039 cites W1964810306 @default.
• W2155373039 cites W1977939286 @default.
• W2155373039 cites W1979813508 @default.
• W2155373039 cites W1986253399 @default.
• W2155373039 cites W1986367732 @default.
• W2155373039 cites W1986821086 @default.
• W2155373039 cites W1993542781 @default.
• W2155373039 cites W1993692084 @default.
• W2155373039 cites W2030057651 @default.
• W2155373039 cites W2034015723 @default.
• W2155373039 cites W2036919408 @default.
• W2155373039 cites W2037855535 @default.
• W2155373039 cites W2041963120 @default.
• W2155373039 cites W2046282439 @default.
• W2155373039 cites W2048393681 @default.
• W2155373039 cites W2061306978 @default.
• W2155373039 cites W2078095857 @default.
• W2155373039 cites W2084835891 @default.
• W2155373039 cites W2088819558 @default.
• W2155373039 cites W2092745317 @default.
• W2155373039 cites W2100556105 @default.
• W2155373039 cites W2125483105 @default.
• W2155373039 cites W2127499576 @default.
• W2155373039 cites W2127869796 @default.
• W2155373039 cites W2128671083 @default.
• W2155373039 cites W2151393439 @default.
• W2155373039 cites W2162934456 @default.
• W2155373039 cites W2163516773 @default.
• W2155373039 cites W2167250741 @default.
• W2155373039 cites W2168161193 @default.
• W2155373039 cites W4231116623 @default.
• W2155373039 cites W4242112041 @default.
• W2155373039 cites W4248539476 @default.
• W2155373039 doi "https://doi.org/10.1093/humrep/dep467" @default.
• W2155373039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2839908" @default.
• W2155373039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20097922" @default.
• W2155373039 hasPublicationYear "2010" @default.
• W2155373039 type Work @default.
• W2155373039 sameAs 2155373039 @default.
• W2155373039 citedByCount "28" @default.
• W2155373039 countsByYear W21553730392012 @default.
• W2155373039 countsByYear W21553730392013 @default.
• W2155373039 countsByYear W21553730392014 @default.
• W2155373039 countsByYear W21553730392015 @default.
• W2155373039 countsByYear W21553730392016 @default.
• W2155373039 countsByYear W21553730392017 @default.
• W2155373039 countsByYear W21553730392018 @default.
• W2155373039 countsByYear W21553730392019 @default.
• W2155373039 countsByYear W21553730392021 @default.
• W2155373039 countsByYear W21553730392022 @default.
• W2155373039 countsByYear W21553730392023 @default.
• W2155373039 crossrefType "journal-article" @default.
• W2155373039 hasAuthorship W2155373039A5011093399 @default.
• W2155373039 hasAuthorship W2155373039A5012039592 @default.
• W2155373039 hasAuthorship W2155373039A5015099322 @default.
• W2155373039 hasAuthorship W2155373039A5020505378 @default.
• W2155373039 hasAuthorship W2155373039A5023969533 @default.
• W2155373039 hasAuthorship W2155373039A5047403775 @default.
• W2155373039 hasAuthorship W2155373039A5070758515 @default.
• W2155373039 hasAuthorship W2155373039A5071942655 @default.
• W2155373039 hasBestOaLocation W21553730391 @default.
• W2155373039 hasConcept C126322002 @default.
• W2155373039 hasConcept C134018914 @default.
• W2155373039 hasConcept C142773365 @default.
• W2155373039 hasConcept C170493617 @default.
• W2155373039 hasConcept C181612422 @default.
• W2155373039 hasConcept C187785154 @default.
• W2155373039 hasConcept C2776176026 @default.
• W2155373039 hasConcept C2776608385 @default.
• W2155373039 hasConcept C2777203538 @default.
• W2155373039 hasConcept C2777330693 @default.
• W2155373039 hasConcept C2778324911 @default.
• W2155373039 hasConcept C71924100 @default.
• W2155373039 hasConcept C79879829 @default.
• W2155373039 hasConcept C86803240 @default.
• W2155373039 hasConcept C95444343 @default.
• W2155373039 hasConceptScore W2155373039C126322002 @default.
• W2155373039 hasConceptScore W2155373039C134018914 @default.
• W2155373039 hasConceptScore W2155373039C142773365 @default.
• W2155373039 hasConceptScore W2155373039C170493617 @default.
• W2155373039 hasConceptScore W2155373039C181612422 @default.
• W2155373039 hasConceptScore W2155373039C187785154 @default.
• W2155373039 hasConceptScore W2155373039C2776176026 @default.
• W2155373039 hasConceptScore W2155373039C2776608385 @default.

• next