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- W2155374583 abstract "Osteocare, a herbal formulation, has been found to be very effective in bone mineralization and support of the microstructure of bone tissue. The water-soluble components of Osteocare (WSCO) induced osteogenic activity in human osteoblast-like SaOS-2 cells. The addition of WSCO (100 μg/ml) to SaOS-2 cells was effective in increasing the cell proliferation by 41.49% and DNA content by 1.9-fold. WSCO increased matrix mineralization in SaOS-2 cells by increased alkaline phosphatase levels and calcium-rich deposits as observed by Alizarin red staining. WSCO markedly increased mRNA expression for osteopontin (OPN), osteocalcin (OCN), type I collagen (Col I) in SaOS-2 cells, and it down-regulated IL-6 mRNA levels in SaOS-2 cells. The present study showed that WSCO plays an important role in osteoblastic bone formation through enhanced activities of ALP, Col I, bone matrix proteins such as OPN and OCN, down-regulation of cytokines like IL-6, as well as promoting mineralization in SaOS-2 cells." @default.
- W2155374583 created "2016-06-24" @default.
- W2155374583 creator A5008052132 @default.
- W2155374583 creator A5060727587 @default.
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- W2155374583 creator A5073588159 @default.
- W2155374583 date "2014-01-01" @default.
- W2155374583 modified "2023-09-30" @default.
- W2155374583 title "Water Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells" @default.
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- W2155374583 doi "https://doi.org/10.3797/scipharm.1310-25" @default.
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