FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155383658> ?p ?o ?g. }

• W2155383658 endingPage "127" @default.
• W2155383658 startingPage "123" @default.
• W2155383658 abstract "Oral leukoplakia is defined as a white patch in the oral cavity that cannot be diagnosed as any other known disorder. These lesions carry an increased risk of malignant progression, and approximately 2-3% per year do progress to cancer. At present biopsies are histopathologically graded for dysplasia to assess the risk of progression, but this grading is somewhat subjective and of limited use for the individual patient. In a previous study we discovered by a comprehensive proteomics approach that compared to normal mucosa, protein expression of cornulin, keratin 4 and keratin 13 is decreased in tumors and severe dysplasia, preneoplastic tissue with a high risk of malignant progression. Here, we studied whether loss of expression of these proteins can predict malignant transformation of oral leukoplakia. Biopsies of 12 progressing and 36 non-progressing leukoplakia lesions were analyzed for cornulin, keratin 4 and keratin 13 expression by immunohistochemistry, and graded for dysplasia. Kaplan-Meier analysis showed that loss of expression of neither cornulin (p=0.075), keratin 4 (p=0.789) nor keratin 13 (p=0.732) was significantly associated with malignant transformation of leukoplakia lesions. However, decreased expression of these proteins was significantly associated with the presence of hyperkeratosis. Only dysplasia grading correlated significantly with malignant progression of leukoplakia (p=0.024). Despite the promising outlook that decreased cornulin, keratin 4 and keratin 13 expression in the oral mucosa is associated with a premalignant state, these markers do not predict malignant transformation of leukoplakia lesions. The most likely explanation is that the aberrant differentiation state of hyperkeratotic leukoplakia lesions already causes a decreased expression, obscuring the putative association with malignant transformation. Our results support the significance of dysplasia grading for the prediction of malignant transformation." @default.
• W2155383658 created "2016-06-24" @default.
• W2155383658 creator A5001519121 @default.
• W2155383658 creator A5036032523 @default.
• W2155383658 creator A5037845155 @default.
• W2155383658 creator A5038008573 @default.
• W2155383658 creator A5053603496 @default.
• W2155383658 creator A5065147823 @default.
• W2155383658 creator A5077403448 @default.
• W2155383658 date "2010-02-01" @default.
• W2155383658 modified "2023-10-09" @default.
• W2155383658 title "Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia" @default.
• W2155383658 cites W1630865570 @default.
• W2155383658 cites W1856235061 @default.
• W2155383658 cites W1965885767 @default.
• W2155383658 cites W1969543424 @default.
• W2155383658 cites W1977651481 @default.
• W2155383658 cites W1988381495 @default.
• W2155383658 cites W1993632446 @default.
• W2155383658 cites W2010721273 @default.
• W2155383658 cites W2024377014 @default.
• W2155383658 cites W2028062404 @default.
• W2155383658 cites W2028975619 @default.
• W2155383658 cites W2033642313 @default.
• W2155383658 cites W2046925107 @default.
• W2155383658 cites W2065906885 @default.
• W2155383658 cites W2066082686 @default.
• W2155383658 cites W2086698289 @default.
• W2155383658 cites W2086941274 @default.
• W2155383658 cites W2138599292 @default.
• W2155383658 cites W2147504123 @default.
• W2155383658 cites W2148104731 @default.
• W2155383658 cites W2159015502 @default.
• W2155383658 cites W2162836321 @default.
• W2155383658 cites W4238350906 @default.
• W2155383658 doi "https://doi.org/10.1016/j.oraloncology.2009.11.012" @default.
• W2155383658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20036603" @default.
• W2155383658 hasPublicationYear "2010" @default.
• W2155383658 type Work @default.
• W2155383658 sameAs 2155383658 @default.
• W2155383658 citedByCount "56" @default.
• W2155383658 countsByYear W21553836582012 @default.
• W2155383658 countsByYear W21553836582013 @default.
• W2155383658 countsByYear W21553836582014 @default.
• W2155383658 countsByYear W21553836582015 @default.
• W2155383658 countsByYear W21553836582016 @default.
• W2155383658 countsByYear W21553836582017 @default.
• W2155383658 countsByYear W21553836582018 @default.
• W2155383658 countsByYear W21553836582019 @default.
• W2155383658 countsByYear W21553836582020 @default.
• W2155383658 countsByYear W21553836582021 @default.
• W2155383658 countsByYear W21553836582022 @default.
• W2155383658 countsByYear W21553836582023 @default.
• W2155383658 crossrefType "journal-article" @default.
• W2155383658 hasAuthorship W2155383658A5001519121 @default.
• W2155383658 hasAuthorship W2155383658A5036032523 @default.
• W2155383658 hasAuthorship W2155383658A5037845155 @default.
• W2155383658 hasAuthorship W2155383658A5038008573 @default.
• W2155383658 hasAuthorship W2155383658A5053603496 @default.
• W2155383658 hasAuthorship W2155383658A5065147823 @default.
• W2155383658 hasAuthorship W2155383658A5077403448 @default.
• W2155383658 hasConcept C121608353 @default.
• W2155383658 hasConcept C126322002 @default.
• W2155383658 hasConcept C142724271 @default.
• W2155383658 hasConcept C18903297 @default.
• W2155383658 hasConcept C204232928 @default.
• W2155383658 hasConcept C2775894508 @default.
• W2155383658 hasConcept C2777286243 @default.
• W2155383658 hasConcept C2777550702 @default.
• W2155383658 hasConcept C2779256057 @default.
• W2155383658 hasConcept C2779409057 @default.
• W2155383658 hasConcept C2779915019 @default.
• W2155383658 hasConcept C2781340805 @default.
• W2155383658 hasConcept C31033888 @default.
• W2155383658 hasConcept C50548948 @default.
• W2155383658 hasConcept C71924100 @default.
• W2155383658 hasConcept C81241287 @default.
• W2155383658 hasConcept C86803240 @default.
• W2155383658 hasConceptScore W2155383658C121608353 @default.
• W2155383658 hasConceptScore W2155383658C126322002 @default.
• W2155383658 hasConceptScore W2155383658C142724271 @default.
• W2155383658 hasConceptScore W2155383658C18903297 @default.
• W2155383658 hasConceptScore W2155383658C204232928 @default.
• W2155383658 hasConceptScore W2155383658C2775894508 @default.
• W2155383658 hasConceptScore W2155383658C2777286243 @default.
• W2155383658 hasConceptScore W2155383658C2777550702 @default.
• W2155383658 hasConceptScore W2155383658C2779256057 @default.
• W2155383658 hasConceptScore W2155383658C2779409057 @default.
• W2155383658 hasConceptScore W2155383658C2779915019 @default.
• W2155383658 hasConceptScore W2155383658C2781340805 @default.
• W2155383658 hasConceptScore W2155383658C31033888 @default.
• W2155383658 hasConceptScore W2155383658C50548948 @default.
• W2155383658 hasConceptScore W2155383658C71924100 @default.
• W2155383658 hasConceptScore W2155383658C81241287 @default.
• W2155383658 hasConceptScore W2155383658C86803240 @default.
• W2155383658 hasIssue "2" @default.
• W2155383658 hasLocation W21553836581 @default.
• W2155383658 hasLocation W21553836582 @default.

• next