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• W2155385178 abstract "Recently, several reports have described cases of in situ mantle cell lymphoma (MCL) in which scattered cyclin D1+ cells were present within the mantle zones of reactive-appearing lymphoid follicles. In this report, we describe an unusual histologic pattern of in situ MCL that was identified in a staging lymph node for colonic adenocarcinoma resected 4 years before a diagnosis of symptomatic MCL. Retrospective immunohistochemical studies showed scattered cyclin D1-expressing cells within otherwise reactive germinal centers but not in the surrounding mantle zones. The presence of early MCL cells limited to reactive germinal centers represents a novel follicular in situ growth pattern for MCL, which overlaps morphologically with reactive follicular hyperplasia and follicular lymphoma and which could have implications for MCL pathogenesis." @default.
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• W2155385178 date "2011-08-01" @default.
• W2155385178 modified "2023-09-27" @default.
• W2155385178 title "Early Lymph Node Involvement by Mantle Cell Lymphoma Limited to the Germinal Center" @default.
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• W2155385178 doi "https://doi.org/10.1309/ajcp6kffgtc8plvr" @default.
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