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• W2155408196 abstract "Cancer cells often display defects in mitochondrial respiration, thus the identification of pathways that promote cell survival under this metabolic state may have therapeutic implications. Here, we report that the targeted ablation of mitochondrial respiration markedly increases expression of Polo-like kinase 2 (PLK2) and that it is required for the in vitro growth of these nonrespiring cells. Furthermore, we identify PLK2 as a kinase that phosphorylates Ser-137 of PLK1, which is sufficient to mediate this survival signal. In vivo, knockdown of PLK2 in an isogenic human cell line with a modest defect in mitochondrial respiration eliminates xenograft formation, indicating that PLK2 activity is necessary for growth of cells with compromised respiration. Our findings delineate a mitochondrial dysfunction responsive cell cycle pathway critical for determining cancer cell outcome." @default.
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• W2155408196 date "2009-08-25" @default.
• W2155408196 modified "2023-10-18" @default.
• W2155408196 title "Polo-like kinases mediate cell survival in mitochondrial dysfunction" @default.
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• W2155408196 doi "https://doi.org/10.1073/pnas.0904229106" @default.
• W2155408196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2732832" @default.
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