FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155409600> ?p ?o ?g. }

• W2155409600 endingPage "3110" @default.
• W2155409600 startingPage "3100" @default.
• W2155409600 abstract "Abstract Heterocyclic aromatic amines (HAAs) generated during the cooking of meats are known to be genotoxic substances able to form covalent bonds with DNA bases after metabolic activation. This work aimed at the investigation of the influence of the local environment of nucleobases along the nucleotidic sequence on its modification induced by two different HAAs, namely 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) and 2‐amino‐3‐methylimidazo[4,5‐ f ]quinoline (IQ), in order to identify possible sequences more susceptible to modification. A systematic study of the neighbouring base effect on the adduction was emphasized. Thus, PhIP and IQ adducts have been synthesized with various T‐rich model single‐strand oligonucleotides displaying different flanking bases (A, G, C or T) at the 3′ or the 5′ side of the targeted guanine, which allowed a comparison of the flanking base effects on adduction. Modified oligonucleotides were then analyzed by high‐performance liquid chromatography (HPLC) coupled to electrospray ionization mass spectrometry. The localization of the modifications induced by PhIP or IQ along the oligonucleotide sequence was achieved by tandem mass spectrometry, and modification yields of the various model sequences were compared. Results indicate a favouring sequence context effect on the G‐C8‐IQ adduct formation with the sequence 5′ GGG 3′ . Although higher than IQ, modification yields observed with PhIP showed a less obvious effect of the neighbouring base on the G‐C8‐PhIP adduct formation, with a preferential sequence 5′ GGA/G/T 3′ . Copyright © 2008 John Wiley & Sons, Ltd." @default.
• W2155409600 created "2016-06-24" @default.
• W2155409600 creator A5013753442 @default.
• W2155409600 creator A5058753660 @default.
• W2155409600 creator A5063525240 @default.
• W2155409600 creator A5067322111 @default.
• W2155409600 date "2008-09-16" @default.
• W2155409600 modified "2023-10-11" @default.
• W2155409600 title "Mass spectrometric investigation of the sequence selectivity for adduction of heterocyclic aromatic amines on single-strand oligonucleotides" @default.
• W2155409600 cites W1965827193 @default.
• W2155409600 cites W1967775878 @default.
• W2155409600 cites W1968381499 @default.
• W2155409600 cites W1977262016 @default.
• W2155409600 cites W1984466882 @default.
• W2155409600 cites W1996320798 @default.
• W2155409600 cites W1998895015 @default.
• W2155409600 cites W1999913271 @default.
• W2155409600 cites W2007335424 @default.
• W2155409600 cites W2007709571 @default.
• W2155409600 cites W2013663568 @default.
• W2155409600 cites W2022320927 @default.
• W2155409600 cites W2023226276 @default.
• W2155409600 cites W2024804350 @default.
• W2155409600 cites W2026971357 @default.
• W2155409600 cites W2027319567 @default.
• W2155409600 cites W2033801553 @default.
• W2155409600 cites W2045948766 @default.
• W2155409600 cites W2046902170 @default.
• W2155409600 cites W2047026102 @default.
• W2155409600 cites W2053865094 @default.
• W2155409600 cites W2059048411 @default.
• W2155409600 cites W2072828753 @default.
• W2155409600 cites W2074310182 @default.
• W2155409600 cites W2079295289 @default.
• W2155409600 cites W2082300861 @default.
• W2155409600 cites W2083178602 @default.
• W2155409600 cites W2084573600 @default.
• W2155409600 cites W2087214026 @default.
• W2155409600 cites W2087222090 @default.
• W2155409600 cites W2088104687 @default.
• W2155409600 cites W2109607779 @default.
• W2155409600 cites W2131158080 @default.
• W2155409600 cites W2132950615 @default.
• W2155409600 cites W2152956996 @default.
• W2155409600 cites W2162496474 @default.
• W2155409600 cites W2185286371 @default.
• W2155409600 cites W2034535189 @default.
• W2155409600 doi "https://doi.org/10.1002/rcm.3707" @default.
• W2155409600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18792919" @default.
• W2155409600 hasPublicationYear "2008" @default.
• W2155409600 type Work @default.
• W2155409600 sameAs 2155409600 @default.
• W2155409600 citedByCount "5" @default.
• W2155409600 countsByYear W21554096002013 @default.
• W2155409600 countsByYear W21554096002017 @default.
• W2155409600 crossrefType "journal-article" @default.
• W2155409600 hasAuthorship W2155409600A5013753442 @default.
• W2155409600 hasAuthorship W2155409600A5058753660 @default.
• W2155409600 hasAuthorship W2155409600A5063525240 @default.
• W2155409600 hasAuthorship W2155409600A5067322111 @default.
• W2155409600 hasConcept C104317684 @default.
• W2155409600 hasConcept C108204754 @default.
• W2155409600 hasConcept C129312508 @default.
• W2155409600 hasConcept C151730666 @default.
• W2155409600 hasConcept C155647269 @default.
• W2155409600 hasConcept C162356407 @default.
• W2155409600 hasConcept C178790620 @default.
• W2155409600 hasConcept C185592680 @default.
• W2155409600 hasConcept C2776309666 @default.
• W2155409600 hasConcept C2778112365 @default.
• W2155409600 hasConcept C2778301229 @default.
• W2155409600 hasConcept C2779343474 @default.
• W2155409600 hasConcept C2779485729 @default.
• W2155409600 hasConcept C31827203 @default.
• W2155409600 hasConcept C40684141 @default.
• W2155409600 hasConcept C43617362 @default.
• W2155409600 hasConcept C512185932 @default.
• W2155409600 hasConcept C552990157 @default.
• W2155409600 hasConcept C55493867 @default.
• W2155409600 hasConcept C61234307 @default.
• W2155409600 hasConcept C71240020 @default.
• W2155409600 hasConcept C86803240 @default.
• W2155409600 hasConceptScore W2155409600C104317684 @default.
• W2155409600 hasConceptScore W2155409600C108204754 @default.
• W2155409600 hasConceptScore W2155409600C129312508 @default.
• W2155409600 hasConceptScore W2155409600C151730666 @default.
• W2155409600 hasConceptScore W2155409600C155647269 @default.
• W2155409600 hasConceptScore W2155409600C162356407 @default.
• W2155409600 hasConceptScore W2155409600C178790620 @default.
• W2155409600 hasConceptScore W2155409600C185592680 @default.
• W2155409600 hasConceptScore W2155409600C2776309666 @default.
• W2155409600 hasConceptScore W2155409600C2778112365 @default.
• W2155409600 hasConceptScore W2155409600C2778301229 @default.
• W2155409600 hasConceptScore W2155409600C2779343474 @default.
• W2155409600 hasConceptScore W2155409600C2779485729 @default.
• W2155409600 hasConceptScore W2155409600C31827203 @default.
• W2155409600 hasConceptScore W2155409600C40684141 @default.
• W2155409600 hasConceptScore W2155409600C43617362 @default.

• next