Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155411872> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2155411872 endingPage "447" @default.
- W2155411872 startingPage "438" @default.
- W2155411872 abstract "Both growth hormone and insulin-like growth factor (IGF)-I are essential for postnatal somatic growth, while exerting distinct effects on energy homeostasis. Although growth hormone controls IGF-I production, whether IGF-I was the exclusive mediator of its growth promotion is still debated. In order to further explore their in vivo interactions in somatic growth as well as in energy homeostasis, we have crossed mutant (MT-IGF) transgenic mice onto the GHR - / - background. As expected, GHR gene deficiency caused growth retardation, including significant decreases in lumbar, femur and total body lengths, as well as decreased bone area, mineral content and mineral density. IGF-I overexpression alone in MT-IGF mice increased the weight, with no significant change in bone mineralization or longitudinal growth. Compared to GHR - / - littermates, overexpressed IGF-I in bitransgenic mice (GHR - / - and MT-IGF positive) exhibited fully restored body weight, lumbar (but not femur) and total body lengths, and normalized overall bone area, mineral content and density. On the other hand, there were significant changes in fasting glucose level, glucose tolerance, lean/fat masses and even adipose histology as a result of the transgenic/knockout double-crossing. IGF-I overexpression normalized glucose tolerance in GHR - / - mice. Intriguingly, on GHR+/ - background of partial growth hormone insensitivity, overexpression of IGF-I caused a significant weight gain. Our results thus establish that the growth defect and bone deficiency caused by lack of growth hormone signaling can be effectively restored by increasing IGF-I production in vivo." @default.
- W2155411872 created "2016-06-24" @default.
- W2155411872 creator A5027541256 @default.
- W2155411872 creator A5034941007 @default.
- W2155411872 creator A5058010200 @default.
- W2155411872 date "2009-10-14" @default.
- W2155411872 modified "2023-10-10" @default.
- W2155411872 title "A general IGF-I overexpression effectively rescued somatic growth and bone deficiency in mice caused by growth hormone receptor knockout" @default.
- W2155411872 cites W1996915447 @default.
- W2155411872 cites W2003921227 @default.
- W2155411872 cites W2013937244 @default.
- W2155411872 cites W2023965832 @default.
- W2155411872 cites W2036523102 @default.
- W2155411872 cites W2039825798 @default.
- W2155411872 cites W2040673222 @default.
- W2155411872 cites W2054121324 @default.
- W2155411872 cites W2075194293 @default.
- W2155411872 cites W2084732252 @default.
- W2155411872 cites W2087090518 @default.
- W2155411872 cites W2094402452 @default.
- W2155411872 cites W2102303758 @default.
- W2155411872 cites W2103096725 @default.
- W2155411872 cites W2109793907 @default.
- W2155411872 cites W2111894013 @default.
- W2155411872 cites W2115073960 @default.
- W2155411872 cites W2132555220 @default.
- W2155411872 cites W2137349730 @default.
- W2155411872 cites W2137898713 @default.
- W2155411872 cites W2140826875 @default.
- W2155411872 cites W2151330968 @default.
- W2155411872 cites W2151427219 @default.
- W2155411872 cites W2154635769 @default.
- W2155411872 cites W2160211696 @default.
- W2155411872 doi "https://doi.org/10.3109/08977190903299270" @default.
- W2155411872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19824875" @default.
- W2155411872 hasPublicationYear "2009" @default.
- W2155411872 type Work @default.
- W2155411872 sameAs 2155411872 @default.
- W2155411872 citedByCount "18" @default.
- W2155411872 countsByYear W21554118722012 @default.
- W2155411872 countsByYear W21554118722013 @default.
- W2155411872 countsByYear W21554118722014 @default.
- W2155411872 countsByYear W21554118722016 @default.
- W2155411872 countsByYear W21554118722017 @default.
- W2155411872 countsByYear W21554118722018 @default.
- W2155411872 countsByYear W21554118722019 @default.
- W2155411872 countsByYear W21554118722020 @default.
- W2155411872 countsByYear W21554118722023 @default.
- W2155411872 crossrefType "journal-article" @default.
- W2155411872 hasAuthorship W2155411872A5027541256 @default.
- W2155411872 hasAuthorship W2155411872A5034941007 @default.
- W2155411872 hasAuthorship W2155411872A5058010200 @default.
- W2155411872 hasConcept C113675107 @default.
- W2155411872 hasConcept C126322002 @default.
- W2155411872 hasConcept C134018914 @default.
- W2155411872 hasConcept C170493617 @default.
- W2155411872 hasConcept C182704531 @default.
- W2155411872 hasConcept C2491326 @default.
- W2155411872 hasConcept C2775960820 @default.
- W2155411872 hasConcept C2778279177 @default.
- W2155411872 hasConcept C2984496839 @default.
- W2155411872 hasConcept C511355011 @default.
- W2155411872 hasConcept C71315377 @default.
- W2155411872 hasConcept C71924100 @default.
- W2155411872 hasConcept C86803240 @default.
- W2155411872 hasConceptScore W2155411872C113675107 @default.
- W2155411872 hasConceptScore W2155411872C126322002 @default.
- W2155411872 hasConceptScore W2155411872C134018914 @default.
- W2155411872 hasConceptScore W2155411872C170493617 @default.
- W2155411872 hasConceptScore W2155411872C182704531 @default.
- W2155411872 hasConceptScore W2155411872C2491326 @default.
- W2155411872 hasConceptScore W2155411872C2775960820 @default.
- W2155411872 hasConceptScore W2155411872C2778279177 @default.
- W2155411872 hasConceptScore W2155411872C2984496839 @default.
- W2155411872 hasConceptScore W2155411872C511355011 @default.
- W2155411872 hasConceptScore W2155411872C71315377 @default.
- W2155411872 hasConceptScore W2155411872C71924100 @default.
- W2155411872 hasConceptScore W2155411872C86803240 @default.
- W2155411872 hasIssue "6" @default.
- W2155411872 hasLocation W21554118721 @default.
- W2155411872 hasLocation W21554118722 @default.
- W2155411872 hasOpenAccess W2155411872 @default.
- W2155411872 hasPrimaryLocation W21554118721 @default.
- W2155411872 hasRelatedWork W1991968580 @default.
- W2155411872 hasRelatedWork W2028039944 @default.
- W2155411872 hasRelatedWork W2044467481 @default.
- W2155411872 hasRelatedWork W2051644961 @default.
- W2155411872 hasRelatedWork W2080787688 @default.
- W2155411872 hasRelatedWork W2093694211 @default.
- W2155411872 hasRelatedWork W2101784990 @default.
- W2155411872 hasRelatedWork W2612793722 @default.
- W2155411872 hasRelatedWork W2746026669 @default.
- W2155411872 hasRelatedWork W4210576375 @default.
- W2155411872 hasVolume "27" @default.
- W2155411872 isParatext "false" @default.
- W2155411872 isRetracted "false" @default.
- W2155411872 magId "2155411872" @default.
- W2155411872 workType "article" @default.