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- W2155429042 abstract "We have identified a gene encoding a heterotrimeric G protein gamma subunit, gng-1, from the filamentous fungus Neurospora crassa. gng-1 possesses a gene structure similar to that of mammalian Ggamma genes, consisting of three exons and two introns, with introns present in both the open reading frame and 5'-untranslated region. The GNG-1 amino acid sequence displays high identity to predicted Ggamma subunits from other filamentous fungi, including Giberella zeae, Cryphonectria parasitica, Trichoderma harzianum, and Magnaporthe grisea. Deletion of gng-1 leads to developmental defects similar to those previously characterized for Deltagnb-1 (Gbeta) mutants. Deltagng-1, Deltagnb-1, and Deltagng-1 Deltagnb-1 strains conidiate inappropriately in submerged cultures and are female sterile, producing aberrant female reproductive structures. Similar to previous results obtained with Deltagnb-1 mutants, loss of gng-1 negatively influences levels of Galpha proteins (GNA-1, GNA-2, and GNA-3) in plasma membrane fractions isolated from various tissues of N. crassa and leads to a significant reduction in the amount of intracellular cyclic AMP. In addition, we show that GNB-1 is essential for maintenance of normal steady-state levels of GNG-1, suggesting a functional interaction between GNB-1 and GNG-1. Direct evidence for a physical association between GNB-1 and GNG-1 in vivo was provided by coimmunoprecipitation." @default.
- W2155429042 created "2016-06-24" @default.
- W2155429042 creator A5048795660 @default.
- W2155429042 creator A5080106283 @default.
- W2155429042 date "2005-02-01" @default.
- W2155429042 modified "2023-09-28" @default.
- W2155429042 title "The Heterotrimeric G-Protein Subunits GNG-1 and GNB-1 Form a Gβγ Dimer Required for Normal Female Fertility, Asexual Development, and Gα Protein Levels in <i>Neurospora crassa</i>" @default.
- W2155429042 cites W1026707726 @default.
- W2155429042 cites W1260885512 @default.
- W2155429042 cites W1492894785 @default.
- W2155429042 cites W1494195183 @default.
- W2155429042 cites W1510140161 @default.
- W2155429042 cites W1530195638 @default.
- W2155429042 cites W1535685087 @default.
- W2155429042 cites W1604834232 @default.
- W2155429042 cites W1758082759 @default.
- W2155429042 cites W1780629085 @default.
- W2155429042 cites W1862042696 @default.
- W2155429042 cites W1867602538 @default.
- W2155429042 cites W1891791960 @default.
- W2155429042 cites W1906126330 @default.
- W2155429042 cites W1935093073 @default.
- W2155429042 cites W1963595092 @default.
- W2155429042 cites W1964420128 @default.
- W2155429042 cites W1973613428 @default.
- W2155429042 cites W1984114573 @default.
- W2155429042 cites W1984247884 @default.
- W2155429042 cites W1984442477 @default.
- W2155429042 cites W1986690357 @default.
- W2155429042 cites W1990113802 @default.
- W2155429042 cites W1992752113 @default.
- W2155429042 cites W2000103116 @default.
- W2155429042 cites W2016644494 @default.
- W2155429042 cites W2025837534 @default.
- W2155429042 cites W2026765646 @default.
- W2155429042 cites W2028125482 @default.
- W2155429042 cites W2032341323 @default.
- W2155429042 cites W2033900668 @default.
- W2155429042 cites W2041014178 @default.
- W2155429042 cites W2041943755 @default.
- W2155429042 cites W2043094343 @default.
- W2155429042 cites W2044713093 @default.
- W2155429042 cites W2047202709 @default.
- W2155429042 cites W2049415603 @default.
- W2155429042 cites W2049753026 @default.
- W2155429042 cites W2052280808 @default.
- W2155429042 cites W2054559471 @default.
- W2155429042 cites W2056910486 @default.
- W2155429042 cites W2066109743 @default.
- W2155429042 cites W2068248480 @default.
- W2155429042 cites W2072442277 @default.
- W2155429042 cites W2079001140 @default.
- W2155429042 cites W2091112155 @default.
- W2155429042 cites W2092881720 @default.
- W2155429042 cites W2094263431 @default.
- W2155429042 cites W2098936547 @default.
- W2155429042 cites W2109743495 @default.
- W2155429042 cites W2123272310 @default.
- W2155429042 cites W2124099910 @default.
- W2155429042 cites W2127932991 @default.
- W2155429042 cites W2128699962 @default.
- W2155429042 cites W2129929465 @default.
- W2155429042 cites W2132417094 @default.
- W2155429042 cites W2132769213 @default.
- W2155429042 cites W2133390601 @default.
- W2155429042 cites W2135587043 @default.
- W2155429042 cites W2139013761 @default.
- W2155429042 cites W2140904426 @default.
- W2155429042 cites W2145543625 @default.
- W2155429042 cites W2150754101 @default.
- W2155429042 cites W2153283433 @default.
- W2155429042 cites W2158714788 @default.
- W2155429042 cites W2160795626 @default.
- W2155429042 cites W2166742500 @default.
- W2155429042 cites W2167493116 @default.
- W2155429042 cites W2168808956 @default.
- W2155429042 cites W2170661560 @default.
- W2155429042 cites W2269422074 @default.
- W2155429042 cites W2331088929 @default.
- W2155429042 cites W2411811561 @default.
- W2155429042 cites W4241165948 @default.
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- W2155429042 doi "https://doi.org/10.1128/ec.4.2.365-378.2005" @default.
- W2155429042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/549333" @default.
- W2155429042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15701799" @default.
- W2155429042 hasPublicationYear "2005" @default.
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