Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155431323> ?p ?o ?g. }
- W2155431323 endingPage "810" @default.
- W2155431323 startingPage "810" @default.
- W2155431323 abstract "In continuation of our endeavors to develop new, potent, selective, and less toxic anti-HIV agents, we describe our structure-based bioisosterism design, synthetic strategy, and structure–activity relationship (SAR) studies that led to the identification of pyridazinylthioacetamides, a novel class of NNRTIs, isosteres of arylazolylthioacetanilide derivatives. Nearly all of the tested compounds inhibited HIV-1 strain IIIB replication in the lower micromolar concentration range (EC50: 0.046–5.46 μM). Notably, the most promising compound 8k exhibited extremely potent inhibitory activity against HIV-1 replication with an EC50 value of 0.046 μM, CC50 of 99.9 μM and the viral selectivity index amounted to 2149. These values were much better than those of NVP (EC50 = 0.09 μM) and DDC (EC50 = 1.04 μM). Compound 8k also exhibited moderate inhibition of enzymatic activity with an IC50 value of 4.06 μM, which was of the same order of magnitude as that of NVP (2.74 μM). Docking calculations were also performed to investigate the binding mode of compound 8k into the non-nucleoside binding site of HIV-1 RT and to rationalize some SARs." @default.
- W2155431323 created "2016-06-24" @default.
- W2155431323 creator A5016741562 @default.
- W2155431323 creator A5027734063 @default.
- W2155431323 creator A5031149051 @default.
- W2155431323 creator A5035339773 @default.
- W2155431323 creator A5035724323 @default.
- W2155431323 creator A5040662398 @default.
- W2155431323 creator A5041250721 @default.
- W2155431323 creator A5059468550 @default.
- W2155431323 creator A5069927986 @default.
- W2155431323 creator A5079837566 @default.
- W2155431323 creator A5091214653 @default.
- W2155431323 date "2013-01-01" @default.
- W2155431323 modified "2023-10-04" @default.
- W2155431323 title "Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach" @default.
- W2155431323 cites W1787470815 @default.
- W2155431323 cites W1911648303 @default.
- W2155431323 cites W1975479066 @default.
- W2155431323 cites W1977282539 @default.
- W2155431323 cites W1978111009 @default.
- W2155431323 cites W1979203246 @default.
- W2155431323 cites W1984234311 @default.
- W2155431323 cites W1991519292 @default.
- W2155431323 cites W1991670386 @default.
- W2155431323 cites W2006016090 @default.
- W2155431323 cites W2007088929 @default.
- W2155431323 cites W2012187236 @default.
- W2155431323 cites W2013056086 @default.
- W2155431323 cites W2031081818 @default.
- W2155431323 cites W2033255134 @default.
- W2155431323 cites W2034136231 @default.
- W2155431323 cites W2038775337 @default.
- W2155431323 cites W2045043030 @default.
- W2155431323 cites W2053818792 @default.
- W2155431323 cites W2060074603 @default.
- W2155431323 cites W2062231842 @default.
- W2155431323 cites W2062744755 @default.
- W2155431323 cites W2063380198 @default.
- W2155431323 cites W2063825413 @default.
- W2155431323 cites W2072779381 @default.
- W2155431323 cites W2073415505 @default.
- W2155431323 cites W2079991727 @default.
- W2155431323 cites W2085313140 @default.
- W2155431323 cites W2103389647 @default.
- W2155431323 cites W2124496337 @default.
- W2155431323 cites W2132109825 @default.
- W2155431323 cites W2153573694 @default.
- W2155431323 cites W2154386828 @default.
- W2155431323 cites W2168926375 @default.
- W2155431323 cites W2173616003 @default.
- W2155431323 cites W2180699268 @default.
- W2155431323 doi "https://doi.org/10.1039/c3md00028a" @default.
- W2155431323 hasPublicationYear "2013" @default.
- W2155431323 type Work @default.
- W2155431323 sameAs 2155431323 @default.
- W2155431323 citedByCount "8" @default.
- W2155431323 countsByYear W21554313232014 @default.
- W2155431323 countsByYear W21554313232015 @default.
- W2155431323 countsByYear W21554313232016 @default.
- W2155431323 countsByYear W21554313232023 @default.
- W2155431323 crossrefType "journal-article" @default.
- W2155431323 hasAuthorship W2155431323A5016741562 @default.
- W2155431323 hasAuthorship W2155431323A5027734063 @default.
- W2155431323 hasAuthorship W2155431323A5031149051 @default.
- W2155431323 hasAuthorship W2155431323A5035339773 @default.
- W2155431323 hasAuthorship W2155431323A5035724323 @default.
- W2155431323 hasAuthorship W2155431323A5040662398 @default.
- W2155431323 hasAuthorship W2155431323A5041250721 @default.
- W2155431323 hasAuthorship W2155431323A5059468550 @default.
- W2155431323 hasAuthorship W2155431323A5069927986 @default.
- W2155431323 hasAuthorship W2155431323A5079837566 @default.
- W2155431323 hasAuthorship W2155431323A5091214653 @default.
- W2155431323 hasBestOaLocation W21554313232 @default.
- W2155431323 hasConcept C118792377 @default.
- W2155431323 hasConcept C159047783 @default.
- W2155431323 hasConcept C159110408 @default.
- W2155431323 hasConcept C161790260 @default.
- W2155431323 hasConcept C185592680 @default.
- W2155431323 hasConcept C193042331 @default.
- W2155431323 hasConcept C202751555 @default.
- W2155431323 hasConcept C21951064 @default.
- W2155431323 hasConcept C2777752112 @default.
- W2155431323 hasConcept C2777752497 @default.
- W2155431323 hasConcept C2780035454 @default.
- W2155431323 hasConcept C3013748606 @default.
- W2155431323 hasConcept C41685203 @default.
- W2155431323 hasConcept C55493867 @default.
- W2155431323 hasConcept C71240020 @default.
- W2155431323 hasConcept C71924100 @default.
- W2155431323 hasConcept C86803240 @default.
- W2155431323 hasConcept C96529984 @default.
- W2155431323 hasConcept C98274493 @default.
- W2155431323 hasConceptScore W2155431323C118792377 @default.
- W2155431323 hasConceptScore W2155431323C159047783 @default.
- W2155431323 hasConceptScore W2155431323C159110408 @default.
- W2155431323 hasConceptScore W2155431323C161790260 @default.
- W2155431323 hasConceptScore W2155431323C185592680 @default.