FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155437022> ?p ?o ?g. }

• W2155437022 endingPage "2210" @default.
• W2155437022 startingPage "2205" @default.
• W2155437022 abstract "Werner syndrome (WS) is a rare human premature aging disease caused by mutations in the gene encoding the RecQ helicase WRN. In addition to the aging features, this disorder is marked by genomic instability, associated with an elevated incidence of cancer. Several lines of evidence suggest that telomere dysfunction is associated with the aging phenotype of the syndrome; however, the origin of the genomic instability observed in WS cells and the reason for the high incidence of cancer in WS have not been established. We previously proposed that WRN helicase activity was necessary to prevent dramatic telomere loss during DNA replication. Here we demonstrate that replication-associated telomere loss is responsible for the chromosome fusions found in WS fibroblasts. Moreover, using metaphase analysis we show that telomere elongation by telomerase can significantly reduce the appearance of new chromosomal aberrations in cells lacking WRN, similar to complementation of WS cells with WRN. Our results suggest that the genome instability in WS cells depends directly on telomere dysfunction, linking chromosome end maintenance to chromosomal aberrations in this disease." @default.
• W2155437022 created "2016-06-24" @default.
• W2155437022 creator A5015972472 @default.
• W2155437022 creator A5027514951 @default.
• W2155437022 creator A5029547484 @default.
• W2155437022 creator A5047597981 @default.
• W2155437022 creator A5078355469 @default.
• W2155437022 date "2007-02-13" @default.
• W2155437022 modified "2023-10-09" @default.
• W2155437022 title "Telomere dysfunction as a cause of genomic instability in Werner syndrome" @default.
• W2155437022 cites W1487697828 @default.
• W2155437022 cites W1496772673 @default.
• W2155437022 cites W1541877559 @default.
• W2155437022 cites W1818287283 @default.
• W2155437022 cites W1926322311 @default.
• W2155437022 cites W1964543951 @default.
• W2155437022 cites W1982306759 @default.
• W2155437022 cites W2004201880 @default.
• W2155437022 cites W2013703669 @default.
• W2155437022 cites W2014013625 @default.
• W2155437022 cites W2021489383 @default.
• W2155437022 cites W2033002463 @default.
• W2155437022 cites W2035389897 @default.
• W2155437022 cites W2050228381 @default.
• W2155437022 cites W2056047802 @default.
• W2155437022 cites W2058197513 @default.
• W2155437022 cites W2064310741 @default.
• W2155437022 cites W2072744580 @default.
• W2155437022 cites W2075206831 @default.
• W2155437022 cites W2077449437 @default.
• W2155437022 cites W2088926897 @default.
• W2155437022 cites W2091170248 @default.
• W2155437022 cites W2094556673 @default.
• W2155437022 cites W2108482850 @default.
• W2155437022 cites W2111723163 @default.
• W2155437022 cites W2115346781 @default.
• W2155437022 cites W2117331734 @default.
• W2155437022 cites W2126815966 @default.
• W2155437022 cites W2144794152 @default.
• W2155437022 cites W2153043528 @default.
• W2155437022 cites W2154837214 @default.
• W2155437022 cites W2155835896 @default.
• W2155437022 cites W2156930669 @default.
• W2155437022 doi "https://doi.org/10.1073/pnas.0609410104" @default.
• W2155437022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1794219" @default.
• W2155437022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17284601" @default.
• W2155437022 hasPublicationYear "2007" @default.
• W2155437022 type Work @default.
• W2155437022 sameAs 2155437022 @default.
• W2155437022 citedByCount "203" @default.
• W2155437022 countsByYear W21554370222012 @default.
• W2155437022 countsByYear W21554370222013 @default.
• W2155437022 countsByYear W21554370222014 @default.
• W2155437022 countsByYear W21554370222015 @default.
• W2155437022 countsByYear W21554370222016 @default.
• W2155437022 countsByYear W21554370222017 @default.
• W2155437022 countsByYear W21554370222018 @default.
• W2155437022 countsByYear W21554370222019 @default.
• W2155437022 countsByYear W21554370222020 @default.
• W2155437022 countsByYear W21554370222021 @default.
• W2155437022 countsByYear W21554370222022 @default.
• W2155437022 countsByYear W21554370222023 @default.
• W2155437022 crossrefType "journal-article" @default.
• W2155437022 hasAuthorship W2155437022A5015972472 @default.
• W2155437022 hasAuthorship W2155437022A5027514951 @default.
• W2155437022 hasAuthorship W2155437022A5029547484 @default.
• W2155437022 hasAuthorship W2155437022A5047597981 @default.
• W2155437022 hasAuthorship W2155437022A5078355469 @default.
• W2155437022 hasBestOaLocation W21554370221 @default.
• W2155437022 hasConcept C104317684 @default.
• W2155437022 hasConcept C127716648 @default.
• W2155437022 hasConcept C140752955 @default.
• W2155437022 hasConcept C143425029 @default.
• W2155437022 hasConcept C161223559 @default.
• W2155437022 hasConcept C177336024 @default.
• W2155437022 hasConcept C178169997 @default.
• W2155437022 hasConcept C188082640 @default.
• W2155437022 hasConcept C2778090637 @default.
• W2155437022 hasConcept C2779672484 @default.
• W2155437022 hasConcept C2780751114 @default.
• W2155437022 hasConcept C2909947164 @default.
• W2155437022 hasConcept C30481170 @default.
• W2155437022 hasConcept C54355233 @default.
• W2155437022 hasConcept C552990157 @default.
• W2155437022 hasConcept C67705224 @default.
• W2155437022 hasConcept C86803240 @default.
• W2155437022 hasConcept C94581717 @default.
• W2155437022 hasConceptScore W2155437022C104317684 @default.
• W2155437022 hasConceptScore W2155437022C127716648 @default.
• W2155437022 hasConceptScore W2155437022C140752955 @default.
• W2155437022 hasConceptScore W2155437022C143425029 @default.
• W2155437022 hasConceptScore W2155437022C161223559 @default.
• W2155437022 hasConceptScore W2155437022C177336024 @default.
• W2155437022 hasConceptScore W2155437022C178169997 @default.
• W2155437022 hasConceptScore W2155437022C188082640 @default.
• W2155437022 hasConceptScore W2155437022C2778090637 @default.
• W2155437022 hasConceptScore W2155437022C2779672484 @default.
• W2155437022 hasConceptScore W2155437022C2780751114 @default.

• next