FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155438906> ?p ?o ?g. }

• W2155438906 endingPage "181" @default.
• W2155438906 startingPage "181" @default.
• W2155438906 abstract "The absence epilepsies are characterized by recurrent episodes of loss of consciousness associated with generalized spike-and-wave discharges, with an abrupt onset and offset, in the thalamocortical system. In the absence of detailed neurophysiological studies in humans, many of the concepts regarding the pathophysiological basis of absence seizures are based on studies in animal models. Each of these models has its particular strengths and limitations, and the validity of findings from these models for the human condition cannot be assumed. Consequently, studies in different models have produced some conflicting findings and conclusions. A long-standing concept, based primarily from studies in vivo in cats and in vitro brain slices, is that these paroxysmal electrical events develop suddenly from sleep-related spindle oscillations. More specifically, it is proposed that the initial mechanisms that underlie absence-related spike-and-wave discharges are located in the thalamus, involving especially the thalamic reticular nucleus. By contrast, more recent studies in well-established, genetic models of absence epilepsy in rats demonstrate that spike-and-wave discharges originate in a cortical focus and develop from a wake-related natural corticothalamic sensorimotor rhythm. In this review we integrate recent findings showing that, in both the thalamus and the neocortex, genetically-determined, absence-related spike-and-wave discharges are the manifestation of hypersynchronized, cellular, rhythmic excitations and inhibitions that result from a combination of complex, intrinsic, synaptic mechanisms. Arguments are put forward supporting the hypothesis that layer VI corticothalamic neurons act as 'drivers' in the generation of spike-and-wave discharges in the somatosensory thalamocortical system that result in corticothalamic resonances particularly initially involving the thalamic reticular nucleus. However an important unresolved question is: what are the cellular and network mechanisms responsible for the switch from physiological, wake-related, natural oscillations into pathological spike-and-wave discharges? We speculate on possible answers to this, building particularly on recent findings from genetic models in rats." @default.
• W2155438906 created "2016-06-24" @default.
• W2155438906 creator A5079459105 @default.
• W2155438906 creator A5084830545 @default.
• W2155438906 date "2005-09-01" @default.
• W2155438906 modified "2023-09-27" @default.
• W2155438906 title "Cellular and network mechanisms of genetically-determined absence seizures" @default.
• W2155438906 cites W113369723 @default.
• W2155438906 cites W1494099841 @default.
• W2155438906 cites W1533320261 @default.
• W2155438906 cites W153759819 @default.
• W2155438906 cites W1546235751 @default.
• W2155438906 cites W1556240983 @default.
• W2155438906 cites W1565233457 @default.
• W2155438906 cites W1583209675 @default.
• W2155438906 cites W1586120944 @default.
• W2155438906 cites W1586815491 @default.
• W2155438906 cites W1610976729 @default.
• W2155438906 cites W1699958347 @default.
• W2155438906 cites W1770278459 @default.
• W2155438906 cites W1809188141 @default.
• W2155438906 cites W1868585274 @default.
• W2155438906 cites W1886118302 @default.
• W2155438906 cites W1964664472 @default.
• W2155438906 cites W1965584252 @default.
• W2155438906 cites W1967114919 @default.
• W2155438906 cites W1971815377 @default.
• W2155438906 cites W1971853010 @default.
• W2155438906 cites W1972694982 @default.
• W2155438906 cites W1973745785 @default.
• W2155438906 cites W1975103185 @default.
• W2155438906 cites W1977060982 @default.
• W2155438906 cites W1978734924 @default.
• W2155438906 cites W1978824962 @default.
• W2155438906 cites W1981179500 @default.
• W2155438906 cites W1985557212 @default.
• W2155438906 cites W1990859989 @default.
• W2155438906 cites W1991424097 @default.
• W2155438906 cites W1991560147 @default.
• W2155438906 cites W1992905903 @default.
• W2155438906 cites W1995957352 @default.
• W2155438906 cites W1999055062 @default.
• W2155438906 cites W2002189290 @default.
• W2155438906 cites W2002811618 @default.
• W2155438906 cites W2007502604 @default.
• W2155438906 cites W2007759028 @default.
• W2155438906 cites W2009089150 @default.
• W2155438906 cites W2009176628 @default.
• W2155438906 cites W2011481926 @default.
• W2155438906 cites W2012590231 @default.
• W2155438906 cites W2013133211 @default.
• W2155438906 cites W2017786715 @default.
• W2155438906 cites W2018760402 @default.
• W2155438906 cites W2020418921 @default.
• W2155438906 cites W2021661569 @default.
• W2155438906 cites W2022890204 @default.
• W2155438906 cites W2024666274 @default.
• W2155438906 cites W2026015475 @default.
• W2155438906 cites W2029046897 @default.
• W2155438906 cites W2029837689 @default.
• W2155438906 cites W2031960958 @default.
• W2155438906 cites W2032950588 @default.
• W2155438906 cites W2035418245 @default.
• W2155438906 cites W2035544035 @default.
• W2155438906 cites W2036925754 @default.
• W2155438906 cites W2038129792 @default.
• W2155438906 cites W2039341631 @default.
• W2155438906 cites W2042036678 @default.
• W2155438906 cites W2042927842 @default.
• W2155438906 cites W2044364684 @default.
• W2155438906 cites W2048244833 @default.
• W2155438906 cites W2049842022 @default.
• W2155438906 cites W2050812535 @default.
• W2155438906 cites W2052285883 @default.
• W2155438906 cites W2052990681 @default.
• W2155438906 cites W2054213975 @default.
• W2155438906 cites W2055143424 @default.
• W2155438906 cites W2058405890 @default.
• W2155438906 cites W2062358209 @default.
• W2155438906 cites W2063464796 @default.
• W2155438906 cites W2063542323 @default.
• W2155438906 cites W2064955374 @default.
• W2155438906 cites W2066759643 @default.
• W2155438906 cites W2067393309 @default.
• W2155438906 cites W2070179975 @default.
• W2155438906 cites W2074162571 @default.
• W2155438906 cites W2074174475 @default.
• W2155438906 cites W2074692940 @default.
• W2155438906 cites W2077658432 @default.
• W2155438906 cites W2078136483 @default.
• W2155438906 cites W2078516477 @default.
• W2155438906 cites W2079981307 @default.
• W2155438906 cites W2081074699 @default.
• W2155438906 cites W2081925468 @default.
• W2155438906 cites W2083370903 @default.
• W2155438906 cites W2084661260 @default.
• W2155438906 cites W2086630321 @default.
• W2155438906 cites W2086840304 @default.

• next