Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155441023> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2155441023 endingPage "119" @default.
- W2155441023 startingPage "113" @default.
- W2155441023 abstract "Therapy with opioids is an exciting new development for arthritis, especially since there is the potential for fewer side effects from molecules that act outside the central nervous system. We have found k-opioid drugs to be powerfully anti-in eammatory, reducing disease severity by as much as 80% and attenuating arthritis in a dose-dependent, stereoselective, antagonist-reversible manner. In contrast, opioids acting at other receptors were therapeutic only at near toxic doses. Currently, however, no pure k-opioids are available for clinical use. The hypothalamic-pituitary-adrenal axis was found to be only partially involved; thus we investigated other neural and immune mechanisms. The results showed that the k-opioid anti-in eammatory actions were exerted via: (1) reduced adhesion molecule expression; (2) inhibition of cell trafecking; (3) reduced tumour necrosis factor release; and (4) alterations in mRNA expression and substance P (SP) and calcitonin gene-related peptide protein in joint tissue. The ability of k-opioids to act at multiple sites in the in eammatory cascade, as suggested by the presence of opioid receptors at various locations throughout the cascade, may explain their powerful actions. k-Opioids are, however, most therapeutic during disease onset; thus it is likely they exert their anti-in eammatory effects predominantly via changes in cellular activation and cytokine expression rather than via the nervous system. The involvement of SP and the efecacy of neurokinin 1 (NK1) antagonists predicts that combined opioid ‐NK1 regimens have therapeutic promise. Peripherally acting opioids may prove to be a potent new treatment for rheumatoid arthritis sufferers in the future." @default.
- W2155441023 created "2016-06-24" @default.
- W2155441023 creator A5084076574 @default.
- W2155441023 date "2001-10-01" @default.
- W2155441023 modified "2023-10-17" @default.
- W2155441023 title "Anti-inflammatory effects of κ-opioids: relevance to rheumatoid arthritis" @default.
- W2155441023 cites W1510301222 @default.
- W2155441023 cites W1524414759 @default.
- W2155441023 cites W1573952482 @default.
- W2155441023 cites W1907318070 @default.
- W2155441023 cites W1937864121 @default.
- W2155441023 cites W1974674594 @default.
- W2155441023 cites W1981072846 @default.
- W2155441023 cites W1998682556 @default.
- W2155441023 cites W2005764829 @default.
- W2155441023 cites W2008178649 @default.
- W2155441023 cites W2011904573 @default.
- W2155441023 cites W2014619986 @default.
- W2155441023 cites W2014957804 @default.
- W2155441023 cites W2015549509 @default.
- W2155441023 cites W2016242983 @default.
- W2155441023 cites W2026733413 @default.
- W2155441023 cites W2037043363 @default.
- W2155441023 cites W2039947092 @default.
- W2155441023 cites W2044202768 @default.
- W2155441023 cites W2056366913 @default.
- W2155441023 cites W2057384920 @default.
- W2155441023 cites W2061825262 @default.
- W2155441023 cites W2066233626 @default.
- W2155441023 cites W2085044981 @default.
- W2155441023 cites W2089686100 @default.
- W2155441023 cites W2126375190 @default.
- W2155441023 cites W2133382298 @default.
- W2155441023 cites W2138586603 @default.
- W2155441023 cites W2318080502 @default.
- W2155441023 cites W2413327243 @default.
- W2155441023 cites W2439515190 @default.
- W2155441023 doi "https://doi.org/10.1191/0968130201pr181ra" @default.
- W2155441023 hasPublicationYear "2001" @default.
- W2155441023 type Work @default.
- W2155441023 sameAs 2155441023 @default.
- W2155441023 citedByCount "1" @default.
- W2155441023 crossrefType "journal-article" @default.
- W2155441023 hasAuthorship W2155441023A5084076574 @default.
- W2155441023 hasConcept C126322002 @default.
- W2155441023 hasConcept C158154518 @default.
- W2155441023 hasConcept C17744445 @default.
- W2155441023 hasConcept C199539241 @default.
- W2155441023 hasConcept C2777575956 @default.
- W2155441023 hasConcept C71924100 @default.
- W2155441023 hasConceptScore W2155441023C126322002 @default.
- W2155441023 hasConceptScore W2155441023C158154518 @default.
- W2155441023 hasConceptScore W2155441023C17744445 @default.
- W2155441023 hasConceptScore W2155441023C199539241 @default.
- W2155441023 hasConceptScore W2155441023C2777575956 @default.
- W2155441023 hasConceptScore W2155441023C71924100 @default.
- W2155441023 hasIssue "3-4" @default.
- W2155441023 hasLocation W21554410231 @default.
- W2155441023 hasOpenAccess W2155441023 @default.
- W2155441023 hasPrimaryLocation W21554410231 @default.
- W2155441023 hasRelatedWork W2041279917 @default.
- W2155441023 hasRelatedWork W2082406232 @default.
- W2155441023 hasRelatedWork W2156283049 @default.
- W2155441023 hasRelatedWork W2316954211 @default.
- W2155441023 hasRelatedWork W2326094713 @default.
- W2155441023 hasRelatedWork W2327246029 @default.
- W2155441023 hasRelatedWork W2427075784 @default.
- W2155441023 hasRelatedWork W2761967325 @default.
- W2155441023 hasRelatedWork W3142209233 @default.
- W2155441023 hasRelatedWork W4245782456 @default.
- W2155441023 hasVolume "8" @default.
- W2155441023 isParatext "false" @default.
- W2155441023 isRetracted "false" @default.
- W2155441023 magId "2155441023" @default.
- W2155441023 workType "article" @default.