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• W2155444316 abstract "The present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats with neuropathic pain induced by lumber 5 (L5) spinal nerve ligation (SNL) in a large size of samples.Adult Sprague-Dawley rats were divided into normal and SNL groups. Electrophysiological technique was used to record the characteristics of WDR neurons in the spinal dorsal horn.Compared with the WDR neurons in normal rats, the WDR neurons in SNL rats showed an increase in excitability, manifested by an enlargement of the receptive field size, an increase in the proportion of neurons that exhibited spontaneous activities, decreases in the C-response threshold and latency, and an increase in the C-response duration. In addition, the numbers of Aβ- and C-fiber-evoked discharges were smaller in SNL rats than in normal rats.The excitability of spinal WDR neurons increased in rats with neuropathic pain induced by L5 SNL. The increase in excitability of WDR neurons may contribute to the development of neuropathic pain." @default.
• W2155444316 created "2016-06-24" @default.
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• W2155444316 date "2011-02-01" @default.
• W2155444316 modified "2023-10-14" @default.
• W2155444316 title "Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation" @default.
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• W2155444316 doi "https://doi.org/10.1007/s12264-011-1039-z" @default.
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• W2155444316 hasPublicationYear "2011" @default.
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