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• W2155448231 abstract "Cisplatin and its analogues are first-line chemotherapeutic agents for the treatment of numerous human cancers. A major inconvenience in their clinical use is their strong tendency to link to sulfur compounds, especially in kidney, ultimately leading to severe nephrotoxicity. To overcome this drawback we prepared a variety of platinum complexes with sulfur ligands and analyzed their biological profiles. Here, a series of six platinum(II) compounds bearing a conserved O,S binding moiety have been synthesized and characterized as experimental anticancer agents. The six compounds differ in the nature of the O,S bidentate β-hydroxydithiocinnamic alkyl ester ligand where both the substituents on the aromatic ring and the length of the alkyl chain may be varied. The two remaining coordination positions at the square-planar platinum(II) center are occupied by a chloride ion and a DMSO molecule. These novel platinum compounds showed an acceptable solubility profile in mixed DMSO–buffer solutions and an appreciable stability at physiological pH as judged from analysis of their time-course UV-visible absorption spectra. Their anti-proliferative and pro-apoptotic activities were tested against the cisplatin-resistant lung cancer cell line A549. Assays revealed significant effects of the sample drugs at low concentrations (in the μmolar range); initial structure-activity-relationships are proposed. The activity of the apoptosis-promoting protein caspase 3/7 was determined; results proved that these novel platinum compounds, under the chosen experimental conditions, preferentially induce apoptosis over necrosis. Reactions with the model proteins cytochrome c, lysozyme and albumin were studied by ESI MS and ICP-OES to gain preliminary mechanistic information. The tested compounds turned out to metalate the mentioned proteins to a large extent. In view of the obtained results these novel platinum complexes qualify themselves as promising cytotoxic agents and merit, in our opinion, a deeper pharmacological evaluation as prospective anticancer agents." @default.
• W2155448231 created "2016-06-24" @default.
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• W2155448231 date "2014-01-01" @default.
• W2155448231 modified "2023-09-30" @default.
• W2155448231 title "Novel platinum(<scp>ii</scp>) compounds with O,S bidentate ligands: synthesis, characterization, antiproliferative properties and biomolecular interactions" @default.
• W2155448231 cites W1613417480 @default.
• W2155448231 cites W1910806696 @default.
• W2155448231 cites W1966519822 @default.
• W2155448231 cites W1966575041 @default.
• W2155448231 cites W1968609308 @default.
• W2155448231 cites W1971490048 @default.
• W2155448231 cites W1976530727 @default.
• W2155448231 cites W1978649563 @default.
• W2155448231 cites W1981159062 @default.
• W2155448231 cites W1983313065 @default.
• W2155448231 cites W1983668219 @default.
• W2155448231 cites W1985080021 @default.
• W2155448231 cites W1985282657 @default.
• W2155448231 cites W1994406380 @default.
• W2155448231 cites W1994459746 @default.
• W2155448231 cites W1995810957 @default.
• W2155448231 cites W1996273492 @default.
• W2155448231 cites W1999712997 @default.
• W2155448231 cites W2002309439 @default.
• W2155448231 cites W2005877813 @default.
• W2155448231 cites W2007809766 @default.
• W2155448231 cites W2015769960 @default.
• W2155448231 cites W2016401253 @default.
• W2155448231 cites W2017030176 @default.
• W2155448231 cites W2018304699 @default.
• W2155448231 cites W2018445164 @default.
• W2155448231 cites W2019478667 @default.
• W2155448231 cites W2020924094 @default.
• W2155448231 cites W2022540448 @default.
• W2155448231 cites W2024593180 @default.
• W2155448231 cites W2027124147 @default.
• W2155448231 cites W2029407558 @default.
• W2155448231 cites W2031544153 @default.
• W2155448231 cites W2033462272 @default.
• W2155448231 cites W2034729390 @default.
• W2155448231 cites W2038717222 @default.
• W2155448231 cites W2041370255 @default.
• W2155448231 cites W2046123391 @default.
• W2155448231 cites W2046713964 @default.
• W2155448231 cites W2048168597 @default.
• W2155448231 cites W2053124238 @default.
• W2155448231 cites W2056116492 @default.
• W2155448231 cites W2060270846 @default.
• W2155448231 cites W2061591859 @default.
• W2155448231 cites W2067416688 @default.
• W2155448231 cites W2067433112 @default.
• W2155448231 cites W2072557746 @default.
• W2155448231 cites W2079086794 @default.
• W2155448231 cites W2088713484 @default.
• W2155448231 cites W2093282189 @default.
• W2155448231 cites W2094636721 @default.
• W2155448231 cites W2095599510 @default.
• W2155448231 cites W2097163370 @default.
• W2155448231 cites W2101203134 @default.
• W2155448231 cites W2102604361 @default.
• W2155448231 cites W2109511270 @default.
• W2155448231 cites W2112531612 @default.
• W2155448231 cites W2120384906 @default.
• W2155448231 cites W2130708058 @default.
• W2155448231 cites W2131350133 @default.
• W2155448231 cites W2139163037 @default.
• W2155448231 cites W2167421852 @default.
• W2155448231 cites W2169513844 @default.
• W2155448231 cites W2169996328 @default.
• W2155448231 cites W2200433921 @default.
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• W2155448231 doi "https://doi.org/10.1039/c3dt52284a" @default.
• W2155448231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24169734" @default.
• W2155448231 hasPublicationYear "2014" @default.
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