FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155448526> ?p ?o ?g. }

• W2155448526 endingPage "278" @default.
• W2155448526 startingPage "267" @default.
• W2155448526 abstract "Abstract This study investigates whether endothelin‐1 (ET‐1) mediates monocrotaline (MCT)‐induced pulmonary artery hypertension (PAH) and right ventricular hypertrophy (RVH), and if so, whether the G‐protein coupled receptor antagonist KMUP‐1 (7‐{2‐[4‐(2‐chlorobenzene)piperazinyl]ethyl}‐1,3‐dimethylxanthine) inhibits ET‐1‐mediated PA constriction and the aforementioned pathological changes. In a chronic rat model, intraperitoneal MCT (60 mg/kg) induced PAH and increased PA medial wall thickening and RV/left ventricle + septum weight ratio on Day 21 after MCT injection. Treatment with sublingual KMUP‐1 (2.5 mg/kg/day) for 21 days prevented these changes and restored vascular endothelial nitric oxide synthase (eNOS) immunohistochemical staining of lung tissues. Western blotting analysis demonstrated that KMUP‐1 enhanced eNOS, soluble guanylate cyclase, and protein kinase G levels, and reduced ET‐1 expression and inactivated Rho kinase II (ROCKII) in MCT‐treated lung tissue over long‐term administration. In MCT‐treated rats, KMUP‐1 decreased plasma ET‐1 on Day 21. KMUP‐1 (3.6 mg/kg) maximally appeared at 0.25 hours in the plasma and declined to basal levels within 24 hours after sublingual administration. In isolated PA of MCT‐treated rats, compared with control and pretreatment with l ‐NG‐nitroarginine methyl ester (100 μM), KMUP‐1 (0.1–100 μM) inhibited ET‐1 (0.01 μM)‐induced vasoconstriction. Endothelium‐denuded PA sustained higher contractility in the presence of KMUP‐1. In a 24‐hour culture of smooth muscle cells (i.e., PA smooth muscle cells or PASMCs), KMUP‐1 (0.1–10 μM) inhibited RhoA‐ and ET‐1‐induced RhoA activation. KMUP‐1 prevented MCT‐induced PAH, PA wall thickening, and RVH by enhancing eNOS and suppressing ET‐1/ROCKII expression. In vitro , KMUP‐1 inhibited ET‐1‐induced PA constriction and ET‐1‐dependent/independent RhoA activation of PASMCs. In summary, KMUP‐1 attenuates ET‐1‐induced/ET‐1‐mediated PA constriction, and could thus aid in the treatment of PAH caused by MCT." @default.
• W2155448526 created "2016-06-24" @default.
• W2155448526 creator A5003091642 @default.
• W2155448526 creator A5007695335 @default.
• W2155448526 creator A5011615090 @default.
• W2155448526 creator A5023317687 @default.
• W2155448526 creator A5024624236 @default.
• W2155448526 creator A5038711068 @default.
• W2155448526 creator A5041835966 @default.
• W2155448526 date "2014-04-30" @default.
• W2155448526 modified "2023-10-17" @default.
• W2155448526 title "Endothelial nitric oxide synthase‐enhancing G‐protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin‐1‐dependent and endothelin‐1‐independent pathways in a monocrotaline model" @default.
• W2155448526 cites W1503549916 @default.
• W2155448526 cites W1504137925 @default.
• W2155448526 cites W1579639018 @default.
• W2155448526 cites W1965244935 @default.
• W2155448526 cites W1969172880 @default.
• W2155448526 cites W1985608717 @default.
• W2155448526 cites W1986858103 @default.
• W2155448526 cites W1992343876 @default.
• W2155448526 cites W1994635773 @default.
• W2155448526 cites W2002676488 @default.
• W2155448526 cites W2005092547 @default.
• W2155448526 cites W2014864594 @default.
• W2155448526 cites W2022921924 @default.
• W2155448526 cites W2025996713 @default.
• W2155448526 cites W2026900256 @default.
• W2155448526 cites W2038938013 @default.
• W2155448526 cites W2043935726 @default.
• W2155448526 cites W2051106500 @default.
• W2155448526 cites W2054162629 @default.
• W2155448526 cites W2057792828 @default.
• W2155448526 cites W2069275891 @default.
• W2155448526 cites W2069826577 @default.
• W2155448526 cites W2073687808 @default.
• W2155448526 cites W2075947831 @default.
• W2155448526 cites W2088117415 @default.
• W2155448526 cites W2097255070 @default.
• W2155448526 cites W2098636543 @default.
• W2155448526 cites W2101100259 @default.
• W2155448526 cites W2109335746 @default.
• W2155448526 cites W2121452261 @default.
• W2155448526 cites W2129938192 @default.
• W2155448526 cites W2132009348 @default.
• W2155448526 cites W2138255707 @default.
• W2155448526 cites W2140507682 @default.
• W2155448526 cites W2145395425 @default.
• W2155448526 cites W2156588778 @default.
• W2155448526 cites W2158379683 @default.
• W2155448526 cites W2160307156 @default.
• W2155448526 cites W2161467739 @default.
• W2155448526 cites W2164154096 @default.
• W2155448526 cites W2168113891 @default.
• W2155448526 cites W2332218975 @default.
• W2155448526 doi "https://doi.org/10.1016/j.kjms.2014.02.014" @default.
• W2155448526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24835346" @default.
• W2155448526 hasPublicationYear "2014" @default.
• W2155448526 type Work @default.
• W2155448526 sameAs 2155448526 @default.
• W2155448526 citedByCount "15" @default.
• W2155448526 countsByYear W21554485262015 @default.
• W2155448526 countsByYear W21554485262016 @default.
• W2155448526 countsByYear W21554485262019 @default.
• W2155448526 countsByYear W21554485262021 @default.
• W2155448526 countsByYear W21554485262022 @default.
• W2155448526 countsByYear W21554485262023 @default.
• W2155448526 crossrefType "journal-article" @default.
• W2155448526 hasAuthorship W2155448526A5003091642 @default.
• W2155448526 hasAuthorship W2155448526A5007695335 @default.
• W2155448526 hasAuthorship W2155448526A5011615090 @default.
• W2155448526 hasAuthorship W2155448526A5023317687 @default.
• W2155448526 hasAuthorship W2155448526A5024624236 @default.
• W2155448526 hasAuthorship W2155448526A5038711068 @default.
• W2155448526 hasAuthorship W2155448526A5041835966 @default.
• W2155448526 hasConcept C126322002 @default.
• W2155448526 hasConcept C134018914 @default.
• W2155448526 hasConcept C144980905 @default.
• W2155448526 hasConcept C149601957 @default.
• W2155448526 hasConcept C170493617 @default.
• W2155448526 hasConcept C2776345702 @default.
• W2155448526 hasConcept C2777622882 @default.
• W2155448526 hasConcept C2778326061 @default.
• W2155448526 hasConcept C2779961880 @default.
• W2155448526 hasConcept C2780930700 @default.
• W2155448526 hasConcept C519581460 @default.
• W2155448526 hasConcept C71924100 @default.
• W2155448526 hasConcept C98274493 @default.
• W2155448526 hasConceptScore W2155448526C126322002 @default.
• W2155448526 hasConceptScore W2155448526C134018914 @default.
• W2155448526 hasConceptScore W2155448526C144980905 @default.
• W2155448526 hasConceptScore W2155448526C149601957 @default.
• W2155448526 hasConceptScore W2155448526C170493617 @default.
• W2155448526 hasConceptScore W2155448526C2776345702 @default.
• W2155448526 hasConceptScore W2155448526C2777622882 @default.
• W2155448526 hasConceptScore W2155448526C2778326061 @default.
• W2155448526 hasConceptScore W2155448526C2779961880 @default.
• W2155448526 hasConceptScore W2155448526C2780930700 @default.
• W2155448526 hasConceptScore W2155448526C519581460 @default.

• next