FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155456520> ?p ?o ?g. }

• W2155456520 endingPage "785" @default.
• W2155456520 startingPage "774" @default.
• W2155456520 abstract "Bidirectional replication of Streptomyces linear plasmids and chromosomes from a central origin produces unpaired 3'-leading-strand overhangs at the telomeres of replication intermediates. Filling in of these overhangs leaves a terminal protein attached covalently to the 5' DNA ends of mature replicons. We report here the essential role of a novel 80-kD DNA-binding protein (telomere-associated protein, Tap) in this process. Biochemical studies, yeast two-hybrid analysis, and immunoprecipitation/immunodepletion experiments indicate that Tap binds tightly to specific sequences in 3' overhangs and also interacts with Tpg, bringing Tpg to telomere termini. Using DNA microarrays to analyze the chromosomes of tap mutant bacteria, we demonstrate that survivors of Tap ablation undergo telomere deletion, chromosome circularization, and amplification of subtelomeric DNA. Microarray-based chromosome mapping at single-ORF resolution revealed common endpoints for independent deletions, identified amplified chromosomal ORFs adjacent to these endpoints, and quantified the copy number of these ORFs. Sequence analysis confirmed chromosome circularization and revealed the insertion of adventitious DNA between joined chromosome ends. Our results show that Tap is required for linear DNA replication in Streptomyces and suggest that it functions to recruit and position Tpg at the telomeres of replication intermediates. They also identify hotspots for the telomeric deletions and subtelomeric DNA amplifications that accompany chromosome circularization." @default.
• W2155456520 created "2016-06-24" @default.
• W2155456520 creator A5037623968 @default.
• W2155456520 creator A5064785053 @default.
• W2155456520 date "2003-03-15" @default.
• W2155456520 modified "2023-10-10" @default.
• W2155456520 title "Recruitment of terminal protein to the ends of<i>Streptomyces</i>linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication" @default.
• W2155456520 cites W1499336739 @default.
• W2155456520 cites W1512052637 @default.
• W2155456520 cites W1554429074 @default.
• W2155456520 cites W1583726729 @default.
• W2155456520 cites W1602550085 @default.
• W2155456520 cites W1723007984 @default.
• W2155456520 cites W1924132532 @default.
• W2155456520 cites W1964653839 @default.
• W2155456520 cites W1970516883 @default.
• W2155456520 cites W1971934147 @default.
• W2155456520 cites W1972068359 @default.
• W2155456520 cites W1972897131 @default.
• W2155456520 cites W1985910710 @default.
• W2155456520 cites W1986351940 @default.
• W2155456520 cites W1987424631 @default.
• W2155456520 cites W1989080074 @default.
• W2155456520 cites W1993591400 @default.
• W2155456520 cites W1994441123 @default.
• W2155456520 cites W1997470075 @default.
• W2155456520 cites W2001315138 @default.
• W2155456520 cites W2012960603 @default.
• W2155456520 cites W2021489383 @default.
• W2155456520 cites W2024974612 @default.
• W2155456520 cites W2026221255 @default.
• W2155456520 cites W2026486008 @default.
• W2155456520 cites W2027840499 @default.
• W2155456520 cites W2042377388 @default.
• W2155456520 cites W2046892466 @default.
• W2155456520 cites W2048649359 @default.
• W2155456520 cites W2063846103 @default.
• W2155456520 cites W2070550263 @default.
• W2155456520 cites W2076825355 @default.
• W2155456520 cites W2077938775 @default.
• W2155456520 cites W2083552513 @default.
• W2155456520 cites W2087251244 @default.
• W2155456520 cites W2095456685 @default.
• W2155456520 cites W2096359570 @default.
• W2155456520 cites W2098661371 @default.
• W2155456520 cites W2100727027 @default.
• W2155456520 cites W2110980305 @default.
• W2155456520 cites W2111179083 @default.
• W2155456520 cites W2112717830 @default.
• W2155456520 cites W2117588164 @default.
• W2155456520 cites W2121444961 @default.
• W2155456520 cites W2122658576 @default.
• W2155456520 cites W2130525093 @default.
• W2155456520 cites W2130538026 @default.
• W2155456520 cites W2132659102 @default.
• W2155456520 cites W2137082459 @default.
• W2155456520 cites W2142383147 @default.
• W2155456520 cites W2150601383 @default.
• W2155456520 cites W2150788604 @default.
• W2155456520 cites W2160041962 @default.
• W2155456520 cites W2161155802 @default.
• W2155456520 cites W2164425579 @default.
• W2155456520 cites W2165011536 @default.
• W2155456520 cites W2175722093 @default.
• W2155456520 cites W2300706651 @default.
• W2155456520 cites W2398161621 @default.
• W2155456520 cites W2417143753 @default.
• W2155456520 cites W2576734941 @default.
• W2155456520 cites W2030640946 @default.
• W2155456520 doi "https://doi.org/10.1101/gad.1060303" @default.
• W2155456520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/196017" @default.
• W2155456520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12651895" @default.
• W2155456520 hasPublicationYear "2003" @default.
• W2155456520 type Work @default.
• W2155456520 sameAs 2155456520 @default.
• W2155456520 citedByCount "89" @default.
• W2155456520 countsByYear W21554565202012 @default.
• W2155456520 countsByYear W21554565202013 @default.
• W2155456520 countsByYear W21554565202014 @default.
• W2155456520 countsByYear W21554565202015 @default.
• W2155456520 countsByYear W21554565202017 @default.
• W2155456520 countsByYear W21554565202018 @default.
• W2155456520 countsByYear W21554565202019 @default.
• W2155456520 countsByYear W21554565202020 @default.
• W2155456520 countsByYear W21554565202021 @default.
• W2155456520 countsByYear W21554565202022 @default.
• W2155456520 countsByYear W21554565202023 @default.
• W2155456520 crossrefType "journal-article" @default.
• W2155456520 hasAuthorship W2155456520A5037623968 @default.
• W2155456520 hasAuthorship W2155456520A5064785053 @default.
• W2155456520 hasBestOaLocation W21554565201 @default.
• W2155456520 hasConcept C153911025 @default.
• W2155456520 hasConcept C177336024 @default.
• W2155456520 hasConcept C18103114 @default.
• W2155456520 hasConcept C22744801 @default.
• W2155456520 hasConcept C54355233 @default.
• W2155456520 hasConcept C552990157 @default.
• W2155456520 hasConcept C73573662 @default.

• next