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- W2155460812 abstract "Triiodothyronine (T3) is specifically bound by nuclei from rat liver and kidney. Binding of T3 at 37 degrees C reaches its maximum at 30 min. In the presence of EDTA (to remove Mg2+) T3 binds to a class of binding sites with an estimated equilibrium association constant (Ka) of 3.3 x 10(10) M(-1) and a maximal binding capacity (MBC) of 3.8 fmol T3/100 mug DNA. In the presence of MgCl2 T3 binds to a second class of binding sites with an estimated Ka of 4.8 x 10(8) M(-1) and a MBC of 123 fmol/100 mug DNA. Among the analogues tested, binding - relative to T3 - of D-T3, triiodothyoacetic acid and desamino-T3 is the same for both classes of binding sites, but relative affinity of thyroxine, D-T4, tetraiodothyroacetic acid and desamino-T4 is 2.5 to 6 times higher for the second class of binding sites than for the first class. The presence of a cytosol binding protein is not a prerequisite for binding of T3 to the nucleus." @default.
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- W2155460812 date "1976-01-01" @default.
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- W2155460812 title "BINDING OF L-TRIIODOTHYRONINE TO ISOLATED RAT LIVER AND KIDNEY NUCLEI UNDER VARIOUS CIRCUMSTANCES" @default.
- W2155460812 doi "https://doi.org/10.1530/acta.0.0810082" @default.
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