FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155462040> ?p ?o ?g. }

• W2155462040 endingPage "2419" @default.
• W2155462040 startingPage "2412" @default.
• W2155462040 abstract "Thiazolidinediones (TZDs), agonists of peroxisome proliferator-activated receptor-γ (PPARγ), improve insulin sensitivity in vivo, and the mechanism remains largely unknown. In this study, we showed that, in Zucker obese (fa/fa) rats, acute (1-day) treatment with both rosiglitazone (a TZD) and a non-TZD PPARγ agonist (nTZD) reduced plasma free fatty acid and insulin levels and, concomitantly, potentiated insulin-stimulated Akt phosphorylation at threonine 308 (Akt-pT308) in adipose and muscle tissues. A similar effect on Akt was observed in liver after a 7-day treatment. The increase in Akt-pT308 was correlated with an increase in Akt phosphorylation at serine 473 (Akt-pS473), tyrosine phosphorylation of insulin receptor β subunit and insulin receptor substrate-1, and serine phosphorylation of glycogen synthase kinase-3α/β. The agonists appeared to potentiate Akt1 phosphorylation in muscle and liver and both Akt1 and Akt2 in adipose. Finally, potentiation of insulin signaling was also observed in isolated adipose tissue ex vivo and differentiated 3T3 L1 adipocytes in vitro, but not in rat primary hepatocytes in vitro. These results suggest that 1) PPARγ agonists acutely potentiate insulin signaling in adipose and muscle tissues and such regulation may be physiologically relevant to insulin sensitization in vivo; 2) the agonists directly target adipose tissues; and 3) the metabolic and signaling effects of the agonists are mediated by structurally distinct PPARγ agonists." @default.
• W2155462040 created "2016-06-24" @default.
• W2155462040 creator A5001720031 @default.
• W2155462040 creator A5003322062 @default.
• W2155462040 creator A5008921533 @default.
• W2155462040 creator A5021684928 @default.
• W2155462040 creator A5025061802 @default.
• W2155462040 creator A5033774555 @default.
• W2155462040 creator A5046386078 @default.
• W2155462040 creator A5048401897 @default.
• W2155462040 creator A5050802921 @default.
• W2155462040 creator A5058358219 @default.
• W2155462040 creator A5082280074 @default.
• W2155462040 creator A5091634411 @default.
• W2155462040 date "2002-08-01" @default.
• W2155462040 modified "2023-10-11" @default.
• W2155462040 title "Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists" @default.
• W2155462040 cites W1494611500 @default.
• W2155462040 cites W1501509481 @default.
• W2155462040 cites W1841050729 @default.
• W2155462040 cites W1852624640 @default.
• W2155462040 cites W1966578585 @default.
• W2155462040 cites W1970312964 @default.
• W2155462040 cites W1972220181 @default.
• W2155462040 cites W1977666051 @default.
• W2155462040 cites W1983128420 @default.
• W2155462040 cites W1986587765 @default.
• W2155462040 cites W1992863478 @default.
• W2155462040 cites W1999123584 @default.
• W2155462040 cites W2011246715 @default.
• W2155462040 cites W2017709679 @default.
• W2155462040 cites W2018679785 @default.
• W2155462040 cites W2030207960 @default.
• W2155462040 cites W2040143421 @default.
• W2155462040 cites W2041398929 @default.
• W2155462040 cites W2046766433 @default.
• W2155462040 cites W2047982128 @default.
• W2155462040 cites W2050092688 @default.
• W2155462040 cites W2053073281 @default.
• W2155462040 cites W2070215280 @default.
• W2155462040 cites W2073638865 @default.
• W2155462040 cites W2074630167 @default.
• W2155462040 cites W2094734472 @default.
• W2155462040 cites W2097838137 @default.
• W2155462040 cites W2106427201 @default.
• W2155462040 cites W2107059210 @default.
• W2155462040 cites W2109607186 @default.
• W2155462040 cites W2118190725 @default.
• W2155462040 cites W2120852510 @default.
• W2155462040 cites W2125090169 @default.
• W2155462040 cites W2125344994 @default.
• W2155462040 cites W2132578543 @default.
• W2155462040 cites W2138226825 @default.
• W2155462040 cites W2147067379 @default.
• W2155462040 cites W2147627625 @default.
• W2155462040 cites W2156053266 @default.
• W2155462040 cites W2157159658 @default.
• W2155462040 cites W2165044377 @default.
• W2155462040 cites W4235343735 @default.
• W2155462040 cites W4244978257 @default.
• W2155462040 cites W4250941467 @default.
• W2155462040 cites W4253603188 @default.
• W2155462040 doi "https://doi.org/10.2337/diabetes.51.8.2412" @default.
• W2155462040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12145152" @default.
• W2155462040 hasPublicationYear "2002" @default.
• W2155462040 type Work @default.
• W2155462040 sameAs 2155462040 @default.
• W2155462040 citedByCount "106" @default.
• W2155462040 countsByYear W21554620402012 @default.
• W2155462040 countsByYear W21554620402013 @default.
• W2155462040 countsByYear W21554620402014 @default.
• W2155462040 countsByYear W21554620402015 @default.
• W2155462040 countsByYear W21554620402016 @default.
• W2155462040 countsByYear W21554620402018 @default.
• W2155462040 countsByYear W21554620402019 @default.
• W2155462040 countsByYear W21554620402022 @default.
• W2155462040 crossrefType "journal-article" @default.
• W2155462040 hasAuthorship W2155462040A5001720031 @default.
• W2155462040 hasAuthorship W2155462040A5003322062 @default.
• W2155462040 hasAuthorship W2155462040A5008921533 @default.
• W2155462040 hasAuthorship W2155462040A5021684928 @default.
• W2155462040 hasAuthorship W2155462040A5025061802 @default.
• W2155462040 hasAuthorship W2155462040A5033774555 @default.
• W2155462040 hasAuthorship W2155462040A5046386078 @default.
• W2155462040 hasAuthorship W2155462040A5048401897 @default.
• W2155462040 hasAuthorship W2155462040A5050802921 @default.
• W2155462040 hasAuthorship W2155462040A5058358219 @default.
• W2155462040 hasAuthorship W2155462040A5082280074 @default.
• W2155462040 hasAuthorship W2155462040A5091634411 @default.
• W2155462040 hasBestOaLocation W21554620401 @default.
• W2155462040 hasConcept C112446052 @default.
• W2155462040 hasConcept C11960822 @default.
• W2155462040 hasConcept C126322002 @default.
• W2155462040 hasConcept C134018914 @default.
• W2155462040 hasConcept C154137905 @default.
• W2155462040 hasConcept C171089720 @default.
• W2155462040 hasConcept C185592680 @default.
• W2155462040 hasConcept C185967709 @default.

• next