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- W2155462253 abstract "Importance of the field: Alzheimer's disease (AD) is the most frequent, age-related neurodegenerative disorder and is characterized by progressive deterioration of cognition and global functioning. The relevance of the cholinergic system for memory, cognition and activities of daily life has been recognized decades ago, and research has demonstrated an early involvement and affection of central cholinergic pathways in the course of AD.Areas covered in this review: Here, we review a body of placebo-controlled studies as well as meta-analyses on the cholinesterase (ChE) inhibitor galantamine, one of only four drugs currently approved for antidementia-therapy in AD.What the reader will gain: The scope of this article is to concisely review the rationale of cholinergic treatment in AD, the chemistry and pharmacology of galantamine and to give a detailed overview of its clinical efficacy, safety, tolerability and potential usability for indications beyond AD.Take home message: Galantamine can improve and stabilize cognitive performance, activities of daily living and behavioral symptoms over the course of 6 months and its efficacy and tolerability are comparable with those of other ChE inhibitors (rivastigmine and donepezil). As long as no other drug therapies with comparable or better clinical efficacy emerge, galantamine will remain one of the standard first-line medications for mild-to-moderate AD." @default.
- W2155462253 created "2016-06-24" @default.
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- W2155462253 creator A5031442012 @default.
- W2155462253 creator A5048619898 @default.
- W2155462253 date "2010-01-29" @default.
- W2155462253 modified "2023-09-27" @default.
- W2155462253 title "Galantamine for Alzheimer's disease" @default.
- W2155462253 cites W144495947 @default.
- W2155462253 cites W1951573135 @default.
- W2155462253 cites W1953027527 @default.
- W2155462253 cites W1968413560 @default.
- W2155462253 cites W1969237548 @default.
- W2155462253 cites W1971320357 @default.
- W2155462253 cites W1972153963 @default.
- W2155462253 cites W1972982304 @default.
- W2155462253 cites W1977302521 @default.
- W2155462253 cites W1979910403 @default.
- W2155462253 cites W1983127199 @default.
- W2155462253 cites W1992999272 @default.
- W2155462253 cites W1994067502 @default.
- W2155462253 cites W1995380852 @default.
- W2155462253 cites W1996776294 @default.
- W2155462253 cites W1997451642 @default.
- W2155462253 cites W2000380420 @default.
- W2155462253 cites W2000837493 @default.
- W2155462253 cites W2004713321 @default.
- W2155462253 cites W2005249481 @default.
- W2155462253 cites W2007050333 @default.
- W2155462253 cites W2010301326 @default.
- W2155462253 cites W2012161540 @default.
- W2155462253 cites W2013781938 @default.
- W2155462253 cites W2014475347 @default.
- W2155462253 cites W2014886338 @default.
- W2155462253 cites W2016149437 @default.
- W2155462253 cites W2016254753 @default.
- W2155462253 cites W2022587387 @default.
- W2155462253 cites W2027250745 @default.
- W2155462253 cites W2030567293 @default.
- W2155462253 cites W2034242899 @default.
- W2155462253 cites W2040899624 @default.
- W2155462253 cites W2040934693 @default.
- W2155462253 cites W2043467860 @default.
- W2155462253 cites W2050876413 @default.
- W2155462253 cites W2051182801 @default.
- W2155462253 cites W2052120607 @default.
- W2155462253 cites W2054106674 @default.
- W2155462253 cites W2058371877 @default.
- W2155462253 cites W2062113336 @default.
- W2155462253 cites W2064793866 @default.
- W2155462253 cites W2067418199 @default.
- W2155462253 cites W2067777747 @default.
- W2155462253 cites W2078446165 @default.
- W2155462253 cites W2078548800 @default.
- W2155462253 cites W2089223747 @default.
- W2155462253 cites W2093374391 @default.
- W2155462253 cites W2095350714 @default.
- W2155462253 cites W2101282109 @default.
- W2155462253 cites W2102343148 @default.
- W2155462253 cites W2104227586 @default.
- W2155462253 cites W2106931873 @default.
- W2155462253 cites W2107327698 @default.
- W2155462253 cites W2107557433 @default.
- W2155462253 cites W2109767181 @default.
- W2155462253 cites W2111963393 @default.
- W2155462253 cites W2115691547 @default.
- W2155462253 cites W2116784956 @default.
- W2155462253 cites W2117134611 @default.
- W2155462253 cites W2122692162 @default.
- W2155462253 cites W2122925474 @default.
- W2155462253 cites W2123052863 @default.
- W2155462253 cites W2123633329 @default.
- W2155462253 cites W2125478828 @default.
- W2155462253 cites W2136407293 @default.
- W2155462253 cites W2136995362 @default.
- W2155462253 cites W2137103253 @default.
- W2155462253 cites W2138878035 @default.
- W2155462253 cites W2142797329 @default.
- W2155462253 cites W2147368709 @default.
- W2155462253 cites W2148286364 @default.
- W2155462253 cites W2151603390 @default.
- W2155462253 cites W2152370183 @default.
- W2155462253 cites W2155036193 @default.
- W2155462253 cites W2156220037 @default.
- W2155462253 cites W2159582508 @default.
- W2155462253 cites W2168956122 @default.
- W2155462253 cites W2170614780 @default.
- W2155462253 cites W3147809110 @default.
- W2155462253 cites W4318600612 @default.
- W2155462253 doi "https://doi.org/10.1517/17425251003592137" @default.
- W2155462253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20113148" @default.
- W2155462253 hasPublicationYear "2010" @default.
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