FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155462955> ?p ?o ?g. }

• W2155462955 abstract "Enterovirus 71 (EV71) infection can induce the apoptosis of infected cells. The aim of this study is to explore the effect of EV71 infection on apoptosis mechanisms in virus-infected human rhabdomyosarcoma (RD) cells. The apoptosis of RD cells was examined using annexin V-FITC/PI by flow cytometry and cytokines were detected by ELISA. Cellular RNA was extracted and transcribed to cDNA. PCR array was employed to analyze the expressions of 84 apoptotic genes from EV71-infected RD cells at 8 and 20 h postinfection, respectively. In addition, the expressions of FasL, caspase, AKT2, JNK1/2, c-Jun and NF-κB proteins were detected by western blotting. Flow cytometry demonstrated that the apoptosis or death of EV71-infected RD cells was increased by 37.1% with a multiplicity of infection (MOI) of 5 at 20 h postinfection. The production of IL-4, IL-10 and TNF-α was enhanced by the subsequent EV71 infection. PCR array revealed significant changes in the expressions of apoptotic genes. Among 84 genes, 42 genes were down-regulated after EV71 infection at 8 h, whereas 32 genes were up-regulated at 20 h postinfection. Moreover, the ligands of TNF superfamily such as FasL, CD40L and TNF-α were significantly up-regulated and enhanced the expressions of apoptosis-related cysteine peptidases, including caspase-10, -8, -7 and -3. In addition, EV71 infection induces the phosphorylation of AKT2, JNK1/2, c-Jun and NF-κB at 20 h postinfection. PCR array for the determination of apoptosis gene expressions is an informative assay in elucidating biological pathways. During the early stage of EV71 infection, the apoptotic process of RD cells is significantly delayed. EV71 infection can also induce the expressions of FasL, TNF-α and CD40L, which contribute to the apoptosis of RD cells." @default.
• W2155462955 created "2016-06-24" @default.
• W2155462955 creator A5005413521 @default.
• W2155462955 creator A5010270772 @default.
• W2155462955 creator A5019545346 @default.
• W2155462955 creator A5026587704 @default.
• W2155462955 creator A5033306822 @default.
• W2155462955 creator A5036697078 @default.
• W2155462955 creator A5045979635 @default.
• W2155462955 creator A5079289072 @default.
• W2155462955 creator A5084477357 @default.
• W2155462955 date "2012-11-28" @default.
• W2155462955 modified "2023-10-07" @default.
• W2155462955 title "Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection" @default.
• W2155462955 cites W150701766 @default.
• W2155462955 cites W1962024916 @default.
• W2155462955 cites W1963557660 @default.
• W2155462955 cites W1979593817 @default.
• W2155462955 cites W1980148349 @default.
• W2155462955 cites W1988381117 @default.
• W2155462955 cites W1994526141 @default.
• W2155462955 cites W1995826732 @default.
• W2155462955 cites W2007423442 @default.
• W2155462955 cites W2008200591 @default.
• W2155462955 cites W2013518376 @default.
• W2155462955 cites W2017093959 @default.
• W2155462955 cites W2017390384 @default.
• W2155462955 cites W2032792568 @default.
• W2155462955 cites W2038169799 @default.
• W2155462955 cites W2038403644 @default.
• W2155462955 cites W2049131071 @default.
• W2155462955 cites W2062785324 @default.
• W2155462955 cites W2073092202 @default.
• W2155462955 cites W2088633231 @default.
• W2155462955 cites W2090829965 @default.
• W2155462955 cites W2094871379 @default.
• W2155462955 cites W2100008113 @default.
• W2155462955 cites W2103263770 @default.
• W2155462955 cites W2103827991 @default.
• W2155462955 cites W2104307484 @default.
• W2155462955 cites W2111528675 @default.
• W2155462955 cites W2112513860 @default.
• W2155462955 cites W2113943474 @default.
• W2155462955 cites W2115588189 @default.
• W2155462955 cites W2126073956 @default.
• W2155462955 cites W2134299232 @default.
• W2155462955 cites W2139727003 @default.
• W2155462955 cites W2140526135 @default.
• W2155462955 cites W2142594520 @default.
• W2155462955 cites W2149146665 @default.
• W2155462955 cites W2157594254 @default.
• W2155462955 cites W2158959772 @default.
• W2155462955 cites W2161226422 @default.
• W2155462955 cites W2162969910 @default.
• W2155462955 cites W2163776632 @default.
• W2155462955 cites W2324437012 @default.
• W2155462955 cites W74173758 @default.
• W2155462955 doi "https://doi.org/10.1186/1471-2334-12-327" @default.
• W2155462955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3536580" @default.
• W2155462955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23191987" @default.
• W2155462955 hasPublicationYear "2012" @default.
• W2155462955 type Work @default.
• W2155462955 sameAs 2155462955 @default.
• W2155462955 citedByCount "29" @default.
• W2155462955 countsByYear W21554629552014 @default.
• W2155462955 countsByYear W21554629552015 @default.
• W2155462955 countsByYear W21554629552016 @default.
• W2155462955 countsByYear W21554629552017 @default.
• W2155462955 countsByYear W21554629552018 @default.
• W2155462955 countsByYear W21554629552019 @default.
• W2155462955 countsByYear W21554629552020 @default.
• W2155462955 countsByYear W21554629552021 @default.
• W2155462955 countsByYear W21554629552022 @default.
• W2155462955 crossrefType "journal-article" @default.
• W2155462955 hasAuthorship W2155462955A5005413521 @default.
• W2155462955 hasAuthorship W2155462955A5010270772 @default.
• W2155462955 hasAuthorship W2155462955A5019545346 @default.
• W2155462955 hasAuthorship W2155462955A5026587704 @default.
• W2155462955 hasAuthorship W2155462955A5033306822 @default.
• W2155462955 hasAuthorship W2155462955A5036697078 @default.
• W2155462955 hasAuthorship W2155462955A5045979635 @default.
• W2155462955 hasAuthorship W2155462955A5079289072 @default.
• W2155462955 hasAuthorship W2155462955A5084477357 @default.
• W2155462955 hasBestOaLocation W21554629551 @default.
• W2155462955 hasConcept C104317684 @default.
• W2155462955 hasConcept C153911025 @default.
• W2155462955 hasConcept C159047783 @default.
• W2155462955 hasConcept C190283241 @default.
• W2155462955 hasConcept C203233990 @default.
• W2155462955 hasConcept C2522874641 @default.
• W2155462955 hasConcept C2777888124 @default.
• W2155462955 hasConcept C2778889330 @default.
• W2155462955 hasConcept C31573885 @default.
• W2155462955 hasConcept C54355233 @default.
• W2155462955 hasConcept C553184892 @default.
• W2155462955 hasConcept C66008609 @default.
• W2155462955 hasConcept C86803240 @default.
• W2155462955 hasConcept C88634738 @default.
• W2155462955 hasConceptScore W2155462955C104317684 @default.
• W2155462955 hasConceptScore W2155462955C153911025 @default.

• next