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• W2155467132 abstract "ABSTRACT Dengue hemorrhagic fever, the severe form of dengue virus infection, is believed to be an immunopathological response to a secondary infection with a heterologous serotype of dengue virus. Dengue virus capsid protein-specific CD4 + cytotoxic T-lymphocyte (CTL) clones were shown to be capable of mediating bystander lysis of non-antigen-presenting target cells. After activation by anti-CD3 or in the presence of unlabeled antigen-presenting target cells, these clones could lyse both Jurkat cells and HepG2 cells as bystander targets. Lysis of HepG2 cells suggests a potential role for CD4 + CTL in the liver involvement observed during dengue virus infection. Three CD4 + CTL clones were demonstrated to lyse cognate, antigen-presenting target cells by a mechanism that primarily involves perforin, while bystander lysis occurred through Fas/Fas ligand interactions. In contrast, one clone used a Fas/Fas ligand mechanism to lyse both cognate and bystander targets. Cytokine production by the CTL clones was also examined. In response to stimulation with D2 antigen, CD4 + T-cell clones produced gamma interferon, tumor necrosis factor alpha (TNF-α) and TNF-β. The data suggest that CD4 + CTL clones may contribute to the immunopathology observed upon secondary dengue virus infections through direct cytolysis and/or cytokine production." @default.
• W2155467132 created "2016-06-24" @default.
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• W2155467132 date "1999-05-01" @default.
• W2155467132 modified "2023-10-17" @default.
• W2155467132 title "Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4 ⁺ Cytotoxic T-Lymphocyte Clones" @default.
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• W2155467132 doi "https://doi.org/10.1128/jvi.73.5.3623-3629.1999" @default.
• W2155467132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104137" @default.
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