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- W2155476411 abstract "The binding of fisetin with human serum albumin (HSA) has been studied at different pH using UV-Vis, FTIR, CD and fluorescence spectroscopic techniques. The binding constants were found to increase with the rise in pH of the media. The negative ΔH° (kJ mol-1) and positive ΔS° (J mol-1 K-1) indicate that fisetin binds to HSA via electrostatic interactions with an initial hydrophobic association that result in a positive ΔS°. In presence of potassium chloride (KCl) the binding constants were found to be decrease. The α-helical content of HSA increased after binding with fisetin as analyzed from both CD and FTIR methods. The site marker displacement studies using fluorescence anisotropy suggest that fisetin binds to the hydrophobic pocket (Site 1, subdomain IIA) of HSA which is in good accordance with the molecular docking study. The change in accessible surface area (ASA) of residues of HSA was calculated to get a better insight into the binding. Keywords: Binding, docking, fisetin, fluorescence and human serum albumin, antioxidant agents, ischemia, atherosclerosis, cardiovascular disease, human mast cells (HMC-1)" @default.
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- W2155476411 date "2012-04-01" @default.
- W2155476411 modified "2023-09-27" @default.
- W2155476411 title "Study of the Interaction Between Fisetin and Human Serum Albumin: A Biophysical Approach" @default.
- W2155476411 doi "https://doi.org/10.2174/092986612800493995" @default.
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