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- W2155481498 abstract "institution. The expression of AR-V7 was assessed by immunohistochemistry in primary tumor for all patients. Cox proportional hazardsmodels were used to evaluate the predictive role of all covariates in the development of CRPC. Time to CRPC and cancer-specific survival curves were estimated using the Kaplan-Meier method and compared by the log-rank test. RESULTS: AR-V7 expression rates in localized PCa, newly diagnosed metastatic PCa, and CRPC tissues were 12.0% (12/100), 21.2% (22/104) and 58.7% (27/46), respectively. The AR-V7 expression rate in CRPC was significantly elevated compared with hormone-sensitive PCa (P < 0.001). Multivariate analysis revealed that AR-V7 expression (HR 1⁄4 2.627, P < 0.001) was an independent predictive factor for CRPC development after adjusting for possible confounders. Furthermore, the expression of AR-V7, which inversely correlated with serum PSA level, was associated with shorter survival in CRPC patients. CONCLUSIONS: The protein AR-V7 level in primary tumor can be used as a predictive marker for the development of CRPC and as a prognostic factor inCRPCpatients.Moreover, therapy targetingAR-V7mayhelp prevent PCa progression and improve prognosis of CRPC patients." @default.
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- W2155481498 date "2015-04-01" @default.
- W2155481498 modified "2023-09-25" @default.
- W2155481498 title "MP88-01 OVEREXPRESSION OF NEUROTROPHINS IN BLADDER OVERACTIVITY IS MODULATED BY EXPRESSION OF MICRORNAS" @default.
- W2155481498 doi "https://doi.org/10.1016/j.juro.2015.02.1834" @default.
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