FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155485008> ?p ?o ?g. }

• W2155485008 endingPage "2360" @default.
• W2155485008 startingPage "2353" @default.
• W2155485008 abstract "SummaryBackground: During cardiac catheterization (CC) in children, unfractionated heparin (UFH) is used for primary prophylaxis of thrombotic events (TE). However, the optimal UFH dose to minimize TE and bleeding in children has yet to be established. Objectives: To (i) objectively assess the incidence of TE and bleeding during pediatric CC using clinical assessment and ultrasound; and (ii) compare a high‐dose vs. low‐dose UFH protocol for thromboprophylaxis. Methods: A randomized controlled trial (RCT) comparing high‐dose UFH (100 units kg−1 bolus, followed by 20 units kg h−1 continuous infusion) vs. low‐dose UFH (50 units kg−1 bolus) during CC. Outcome assessment was by clinical examination and vascular ultrasound, performed by blinded examiners before and within 48 h after CC. Children with no consent for randomization were followed in a cohort receiving standard‐of‐care UFH (parallel‐cohort RCT). Results: A total of 227 children were included; 137 were randomized and 90 followed in the cohort study. The overall incidence of TE was 4.6% and bleeding 6.6%. The RCT was stopped early for futility as there were no differences between the high‐dose and the low‐dose UFH in TE (5% vs. 3%; risk ratios [RR] 1.5, 95% confidence interval [CI] 0.3; 9) and bleeding (7% vs. 12%, RR 0.6, 95% CI 0.2; 2). There were also no differences when RCT and cohort study populations were combined. Conclusions: The incidences of TE and bleeding during CC in children were low. There were no differences between the high‐dose and the low‐dose UFH protocols studied. Although Heparin Anticoagulation Randomized Trial in Cardiac Catheterization (HEARTCAT) was not designed as non‐inferiority trial, low‐dose UFH (50 units kg−1 bolus) appears sufficient for thromboprophylaxis during CC. Background: During cardiac catheterization (CC) in children, unfractionated heparin (UFH) is used for primary prophylaxis of thrombotic events (TE). However, the optimal UFH dose to minimize TE and bleeding in children has yet to be established. Objectives: To (i) objectively assess the incidence of TE and bleeding during pediatric CC using clinical assessment and ultrasound; and (ii) compare a high‐dose vs. low‐dose UFH protocol for thromboprophylaxis. Methods: A randomized controlled trial (RCT) comparing high‐dose UFH (100 units kg−1 bolus, followed by 20 units kg h−1 continuous infusion) vs. low‐dose UFH (50 units kg−1 bolus) during CC. Outcome assessment was by clinical examination and vascular ultrasound, performed by blinded examiners before and within 48 h after CC. Children with no consent for randomization were followed in a cohort receiving standard‐of‐care UFH (parallel‐cohort RCT). Results: A total of 227 children were included; 137 were randomized and 90 followed in the cohort study. The overall incidence of TE was 4.6% and bleeding 6.6%. The RCT was stopped early for futility as there were no differences between the high‐dose and the low‐dose UFH in TE (5% vs. 3%; risk ratios [RR] 1.5, 95% confidence interval [CI] 0.3; 9) and bleeding (7% vs. 12%, RR 0.6, 95% CI 0.2; 2). There were also no differences when RCT and cohort study populations were combined. Conclusions: The incidences of TE and bleeding during CC in children were low. There were no differences between the high‐dose and the low‐dose UFH protocols studied. Although Heparin Anticoagulation Randomized Trial in Cardiac Catheterization (HEARTCAT) was not designed as non‐inferiority trial, low‐dose UFH (50 units kg−1 bolus) appears sufficient for thromboprophylaxis during CC." @default.
• W2155485008 created "2016-06-24" @default.
• W2155485008 creator A5011097737 @default.
• W2155485008 creator A5014494615 @default.
• W2155485008 creator A5043040537 @default.
• W2155485008 creator A5052816766 @default.
• W2155485008 creator A5074097141 @default.
• W2155485008 creator A5074594620 @default.
• W2155485008 creator A5090501231 @default.
• W2155485008 creator A5090622562 @default.
• W2155485008 date "2011-12-01" @default.
• W2155485008 modified "2023-10-06" @default.
• W2155485008 title "Incidence of thrombotic and bleeding complications during cardiac catheterization in children: comparison of high‐dose vs. low‐dose heparin protocols" @default.
• W2155485008 cites W1527283637 @default.
• W2155485008 cites W1971074773 @default.
• W2155485008 cites W1976249987 @default.
• W2155485008 cites W1979205094 @default.
• W2155485008 cites W1980563337 @default.
• W2155485008 cites W1986642995 @default.
• W2155485008 cites W1994140802 @default.
• W2155485008 cites W1995020997 @default.
• W2155485008 cites W1997351760 @default.
• W2155485008 cites W1998145823 @default.
• W2155485008 cites W2005797132 @default.
• W2155485008 cites W2009527964 @default.
• W2155485008 cites W2012813569 @default.
• W2155485008 cites W2012855554 @default.
• W2155485008 cites W2020538652 @default.
• W2155485008 cites W2021591474 @default.
• W2155485008 cites W2022604527 @default.
• W2155485008 cites W2028893981 @default.
• W2155485008 cites W2041303686 @default.
• W2155485008 cites W2042158584 @default.
• W2155485008 cites W2045816462 @default.
• W2155485008 cites W2050049140 @default.
• W2155485008 cites W2053416947 @default.
• W2155485008 cites W2058865312 @default.
• W2155485008 cites W2071719603 @default.
• W2155485008 cites W2077961038 @default.
• W2155485008 cites W2083087741 @default.
• W2155485008 cites W2084455569 @default.
• W2155485008 cites W2087102325 @default.
• W2155485008 cites W2088910680 @default.
• W2155485008 cites W2096146076 @default.
• W2155485008 cites W2131236362 @default.
• W2155485008 cites W2138126173 @default.
• W2155485008 cites W2158675631 @default.
• W2155485008 cites W2161183750 @default.
• W2155485008 cites W2273523681 @default.
• W2155485008 cites W2399805068 @default.
• W2155485008 doi "https://doi.org/10.1111/j.1538-7836.2011.04539.x" @default.
• W2155485008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22008390" @default.
• W2155485008 hasPublicationYear "2011" @default.
• W2155485008 type Work @default.
• W2155485008 sameAs 2155485008 @default.
• W2155485008 citedByCount "30" @default.
• W2155485008 countsByYear W21554850082012 @default.
• W2155485008 countsByYear W21554850082013 @default.
• W2155485008 countsByYear W21554850082014 @default.
• W2155485008 countsByYear W21554850082015 @default.
• W2155485008 countsByYear W21554850082016 @default.
• W2155485008 countsByYear W21554850082017 @default.
• W2155485008 countsByYear W21554850082018 @default.
• W2155485008 countsByYear W21554850082019 @default.
• W2155485008 countsByYear W21554850082020 @default.
• W2155485008 countsByYear W21554850082021 @default.
• W2155485008 countsByYear W21554850082022 @default.
• W2155485008 countsByYear W21554850082023 @default.
• W2155485008 crossrefType "journal-article" @default.
• W2155485008 hasAuthorship W2155485008A5011097737 @default.
• W2155485008 hasAuthorship W2155485008A5014494615 @default.
• W2155485008 hasAuthorship W2155485008A5043040537 @default.
• W2155485008 hasAuthorship W2155485008A5052816766 @default.
• W2155485008 hasAuthorship W2155485008A5074097141 @default.
• W2155485008 hasAuthorship W2155485008A5074594620 @default.
• W2155485008 hasAuthorship W2155485008A5090501231 @default.
• W2155485008 hasAuthorship W2155485008A5090622562 @default.
• W2155485008 hasBestOaLocation W21554850081 @default.
• W2155485008 hasConcept C120665830 @default.
• W2155485008 hasConcept C121332964 @default.
• W2155485008 hasConcept C126322002 @default.
• W2155485008 hasConcept C141071460 @default.
• W2155485008 hasConcept C168563851 @default.
• W2155485008 hasConcept C201903717 @default.
• W2155485008 hasConcept C204243189 @default.
• W2155485008 hasConcept C43376680 @default.
• W2155485008 hasConcept C44249647 @default.
• W2155485008 hasConcept C61511704 @default.
• W2155485008 hasConcept C71924100 @default.
• W2155485008 hasConcept C72563966 @default.
• W2155485008 hasConcept C82789193 @default.
• W2155485008 hasConcept C88879693 @default.
• W2155485008 hasConceptScore W2155485008C120665830 @default.
• W2155485008 hasConceptScore W2155485008C121332964 @default.
• W2155485008 hasConceptScore W2155485008C126322002 @default.
• W2155485008 hasConceptScore W2155485008C141071460 @default.
• W2155485008 hasConceptScore W2155485008C168563851 @default.
• W2155485008 hasConceptScore W2155485008C201903717 @default.

• next