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- W2155486504 abstract "We identified new lead candidates which showed potent dual inhibition against phosphodiesterase-1 and 5 by a ligand-based virtual screening optimized for lead evolution. This virtual screening method, consisting of classification and regression tree analysis using 168 2-center pharmacophore descriptors and 12 macroscopic descriptors, demonstrated a high predictive ability for bioactivity of new chemical compounds. The obtained lead candidates were structurally diverse, although only the structure-activity relationship data of hydroxamic acid derivatives were used to configure the prediction model for the virtual screening." @default.
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- W2155486504 date "2006-03-01" @default.
- W2155486504 modified "2023-10-18" @default.
- W2155486504 title "Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution" @default.
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- W2155486504 doi "https://doi.org/10.1016/j.bmcl.2005.11.046" @default.
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