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• W2155486870 abstract "Peripheral nerves and blood vessels travel together closely during development but little is known about their interactions post-injury. The SIV-infected pigtailed macaque model of human immunodeficiency virus (HIV) recapitulates peripheral nervous system pathology of HIV infection. In this study, we assessed the effect of SIV infection on neurovascular regrowth using a validated excisional axotomy model. Six uninfected and five SIV-infected macaques were studied 14 and 70 days after axotomy to characterize regenerating vessels and axons. Blood vessel extension preceded the appearance of regenerating nerve fibers suggesting that vessels serve as scaffolding to guide regenerating axons through extracellular matrix. Vascular endothelial growth factor (VEGF) was expressed along vascular silhouettes by endothelial cells, pericytes, and perivascular cells. VEGF expression correlated with dermal nerve (r = 0.68, p = 0.01) and epidermal nerve fiber regrowth (r = 0.63, p = 0.02). No difference in blood vessel growth was observed between SIV-infected and control macaques. In contrast, SIV-infected animals demonstrated altered length, pruning and arborization of nerve fibers as well as alteration of VEGF expression. These results reinforce earlier human primate findings that vessel growth precedes and influences axonal regeneration. The consistency of these observations across human and non-human primates validates the use of the pigtailed-macaque as a preclinical model." @default.
• W2155486870 created "2016-06-24" @default.
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• W2155486870 date "2012-05-02" @default.
• W2155486870 modified "2023-10-03" @default.
• W2155486870 title "SIV-induced impairment of neurovascular repair: a potential role for VEGF" @default.
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• W2155486870 cites W1965136025 @default.
• W2155486870 cites W1967291020 @default.
• W2155486870 cites W1971248512 @default.
• W2155486870 cites W1974107618 @default.
• W2155486870 cites W1981265720 @default.
• W2155486870 cites W1982542580 @default.
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• W2155486870 cites W1997300044 @default.
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• W2155486870 doi "https://doi.org/10.1007/s13365-012-0102-5" @default.
• W2155486870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3804009" @default.
• W2155486870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22549763" @default.
• W2155486870 hasPublicationYear "2012" @default.
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