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- W2155487079 abstract "Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition (EMT) programs and the induction of tissue-invasive activity, but pro-oncogenic events capable of regulating Snail1 activity remain largely uncharacterized. Herein, we demonstrate that p53 loss-of-function or mutation promotes cancer cell EMT by de-repressing Snail1 protein expression and activity. In the absence of wild-type p53 function, Snail1-dependent EMT is activated in colon, breast, and lung carcinoma cells as a consequence of a decrease in miRNA-34 levels, which suppress Snail1 activity by binding to highly conserved 3' untranslated regions in Snail1 itself as well as those of key Snail1 regulatory molecules, including β-catenin, LEF1, and Axin2. Although p53 activity can impact cell cycle regulation, apoptosis, and DNA repair pathways, the EMT and invasion programs initiated by p53 loss of function or mutation are completely dependent on Snail1 expression. These results identify a new link between p53, miR-34, and Snail1 in the regulation of cancer cell EMT programs." @default.
- W2155487079 created "2016-06-24" @default.
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- W2155487079 date "2011-10-24" @default.
- W2155487079 modified "2023-10-16" @default.
- W2155487079 title "A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition" @default.
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- W2155487079 cites W1650797637 @default.
- W2155487079 cites W1964081206 @default.
- W2155487079 cites W1964719993 @default.
- W2155487079 cites W1967137553 @default.
- W2155487079 cites W1968075505 @default.
- W2155487079 cites W1975293659 @default.
- W2155487079 cites W1979858258 @default.
- W2155487079 cites W1986415115 @default.
- W2155487079 cites W1989562366 @default.
- W2155487079 cites W1994242450 @default.
- W2155487079 cites W1999612336 @default.
- W2155487079 cites W2002376765 @default.
- W2155487079 cites W2006173503 @default.
- W2155487079 cites W2007754809 @default.
- W2155487079 cites W2009410973 @default.
- W2155487079 cites W2014691022 @default.
- W2155487079 cites W2022346609 @default.
- W2155487079 cites W2023332224 @default.
- W2155487079 cites W2024531852 @default.
- W2155487079 cites W2025647419 @default.
- W2155487079 cites W2027892036 @default.
- W2155487079 cites W2035396934 @default.
- W2155487079 cites W2038167014 @default.
- W2155487079 cites W2039382131 @default.
- W2155487079 cites W2042198997 @default.
- W2155487079 cites W2050465180 @default.
- W2155487079 cites W2051663161 @default.
- W2155487079 cites W2059848983 @default.
- W2155487079 cites W2064086023 @default.
- W2155487079 cites W2066441178 @default.
- W2155487079 cites W2066550173 @default.
- W2155487079 cites W2069346669 @default.
- W2155487079 cites W2070765029 @default.
- W2155487079 cites W2080125477 @default.
- W2155487079 cites W2081743768 @default.
- W2155487079 cites W2083158631 @default.
- W2155487079 cites W2087227011 @default.
- W2155487079 cites W2092902276 @default.
- W2155487079 cites W2093364931 @default.
- W2155487079 cites W2095202492 @default.
- W2155487079 cites W2099987999 @default.
- W2155487079 cites W2109155259 @default.
- W2155487079 cites W2111655556 @default.
- W2155487079 cites W2111814753 @default.
- W2155487079 cites W2112880435 @default.
- W2155487079 cites W2114154136 @default.
- W2155487079 cites W2114786335 @default.
- W2155487079 cites W2118102354 @default.
- W2155487079 cites W2119337308 @default.
- W2155487079 cites W2121937053 @default.
- W2155487079 cites W2122483745 @default.
- W2155487079 cites W2124826504 @default.
- W2155487079 cites W2125602642 @default.
- W2155487079 cites W2126426563 @default.
- W2155487079 cites W2132790996 @default.
- W2155487079 cites W2134203671 @default.
- W2155487079 cites W2134361367 @default.
- W2155487079 cites W2135737620 @default.
- W2155487079 cites W2138929006 @default.
- W2155487079 cites W2144154026 @default.
- W2155487079 cites W2144963939 @default.
- W2155487079 cites W2150417542 @default.
- W2155487079 cites W2151909352 @default.
- W2155487079 cites W2153641624 @default.
- W2155487079 cites W2155131748 @default.
- W2155487079 cites W2157903318 @default.
- W2155487079 cites W2160998038 @default.
- W2155487079 cites W2161025693 @default.
- W2155487079 cites W2162075740 @default.
- W2155487079 cites W2167291962 @default.
- W2155487079 cites W2167534419 @default.
- W2155487079 cites W2170581753 @default.
- W2155487079 cites W2171254735 @default.
- W2155487079 doi "https://doi.org/10.1083/jcb.201103097" @default.
- W2155487079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3206336" @default.
- W2155487079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22024162" @default.
- W2155487079 hasPublicationYear "2011" @default.