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- W2155489944 endingPage "a015610" @default.
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- W2155489944 abstract "Transplantation of the pancreas, either as a solid organ or as isolated islets of Langerhans, is indicated in a small proportion of patients with insulin-dependent diabetes in whom severe complications develop, particularly severe glycemic instability and progressive secondary complications (usually renal failure). The potential to reverse diabetes has to be balanced against the morbidity of long-term immunosuppression. For a patient with renal failure, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK), whereas for a patient with glycemic instability, specifically hypoglycemic unawareness, the choice between a solid organ and an islet transplant has to be individual to the patient. Results of SPK transplantation are comparable to other solid-organ transplants (kidney, liver, heart) and there is evidence of improved quality of life and life expectancy, but the results of solitary pancreas transplantation and islets are inferior with respect to graft survival. There is some evidence of benefit with respect to the progression of secondary diabetic complications in patients with functioning transplants for several years." @default.
- W2155489944 created "2016-06-24" @default.
- W2155489944 creator A5035148818 @default.
- W2155489944 creator A5053856483 @default.
- W2155489944 creator A5055986570 @default.
- W2155489944 date "2014-03-10" @default.
- W2155489944 modified "2023-10-15" @default.
- W2155489944 title "Pancreas Transplantation: Solid Organ and Islet" @default.
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- W2155489944 doi "https://doi.org/10.1101/cshperspect.a015610" @default.
- W2155489944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3968790" @default.
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- W2155489944 hasPublicationYear "2014" @default.
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