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• W2155493020 endingPage "1172" @default.
• W2155493020 startingPage "1169" @default.
• W2155493020 abstract "Limited data in humans and animals indicate that excess vitamin A stimulates bone resorption and inhibits bone formation, effects that over time might lead to bone loss and fracture. Thus, it is possible that vitamin A supplementation is a currently unrecognized risk factor for the development of osteoporosis. To further evaluate this possibility, a prospective, randomized, single-blind study of vitamin A supplementation was conducted in 80 healthy men age 18–58 y. One half received 7576 μg (25,000 iu) of retinol palmitate daily with their evening meal; the others took a placebo. Blood was collected from fasting subjects and serum prepared at baseline and after 2, 4 and 6 wk of supplementation. Serum bone specific alkaline phosphatase (BSAP) and N-Telopeptide of type 1 collagen (NTx) were measured at all time points. Serum osteocalcin (Oc) was measured at baseline and after 6 wk of supplementation. BSAP, NTx and Oc did not differ between the supplemented and placebo-treated groups over the course of the study. In conclusion, short-term vitamin A supplementation at this dosage in healthy men does not alter serum markers of skeletal turnover. Thus, it is unlikely that short-term administration of vitamin A would contribute to the development of osteoporosis. Whether long-term vitamin A supplementation might have adverse skeletal effects remains to be determined." @default.
• W2155493020 created "2016-06-24" @default.
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• W2155493020 date "2002-06-01" @default.
• W2155493020 modified "2023-10-10" @default.
• W2155493020 title "Short-Term Vitamin A Supplementation Does Not Affect Bone Turnover in Men" @default.
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• W2155493020 doi "https://doi.org/10.1093/jn/132.6.1169" @default.
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