Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155527722> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2155527722 endingPage "76" @default.
- W2155527722 startingPage "66" @default.
- W2155527722 abstract "Cytogenetic analysis of short-term cultures from 105 squamous cell carcinomas of the larynx (LSCC) revealed clonal chromosome aberrations in 56 tumors. Simple karyotypic changes (less than four aberrations per clone) were found in 24 cases, and the remaining 32 tumors had complex karyotypes with multiple numerical as well as unbalanced structural rearrangements. Extensive intratumor heterogeneity, in the form of multiple related subclones or unrelated clones, was observed in a large fraction of the tumors. The structural changes most often affected chromosomes 3, 1, 11, 7, 2, 15, 5, 4, 8, and 12, with rearrangements in the centromeric regions, i.e., the centromeric bands p10 and q10 and the juxtacentromeric bands p11 and q11, accounting for 43% of the total breakpoints. The most common imbalances brought about by numerical and unbalanced structural rearrangements were loss of chromosomal region 3p21-pter, chromosome arms 4p, 6q, 8p, 10p, 13p, 14p, 15p, and 17p, and gain of chromosomal regions 3q21-qter, 7q31-pter, and 8q. Among 17 recurrent aberrations identified, the most common were i(8q), hsr(11)(q13), i(3q), i(5p), and del(3)(p11). No statistically significant association was found between major karyotypic features and histological differentiation or TNM stage. The karyotypic features of the LSCC were also compared with previously published oral SCC, a subgroup of SCC that has been more extensively characterized cytogenetically. No clear-cut karyotypic differences were found between LSCC and oral SCC, with the exception that i(8q) was significantly more frequent among the latter." @default.
- W2155527722 created "2016-06-24" @default.
- W2155527722 creator A5063155446 @default.
- W2155527722 creator A5075271571 @default.
- W2155527722 creator A5082512703 @default.
- W2155527722 creator A5088709163 @default.
- W2155527722 creator A5090660663 @default.
- W2155527722 date "2000-05-01" @default.
- W2155527722 modified "2023-10-18" @default.
- W2155527722 title "Nonrandom pattern of cytogenetic abnormalities in squamous cell carcinoma of the larynx" @default.
- W2155527722 cites W1964947899 @default.
- W2155527722 cites W1977895628 @default.
- W2155527722 cites W1978800919 @default.
- W2155527722 cites W1984690136 @default.
- W2155527722 cites W1990582989 @default.
- W2155527722 cites W2036696412 @default.
- W2155527722 cites W2040963328 @default.
- W2155527722 cites W2045347862 @default.
- W2155527722 cites W2060537778 @default.
- W2155527722 cites W2089715890 @default.
- W2155527722 cites W2095162144 @default.
- W2155527722 cites W4211161220 @default.
- W2155527722 cites W4234474797 @default.
- W2155527722 cites W4300755731 @default.
- W2155527722 doi "https://doi.org/10.1002/(sici)1098-2264(200005)28:1<66::aid-gcc8>3.0.co;2-4" @default.
- W2155527722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10738304" @default.
- W2155527722 hasPublicationYear "2000" @default.
- W2155527722 type Work @default.
- W2155527722 sameAs 2155527722 @default.
- W2155527722 citedByCount "42" @default.
- W2155527722 countsByYear W21555277222012 @default.
- W2155527722 countsByYear W21555277222013 @default.
- W2155527722 countsByYear W21555277222014 @default.
- W2155527722 countsByYear W21555277222015 @default.
- W2155527722 countsByYear W21555277222017 @default.
- W2155527722 countsByYear W21555277222019 @default.
- W2155527722 crossrefType "journal-article" @default.
- W2155527722 hasAuthorship W2155527722A5063155446 @default.
- W2155527722 hasAuthorship W2155527722A5075271571 @default.
- W2155527722 hasAuthorship W2155527722A5082512703 @default.
- W2155527722 hasAuthorship W2155527722A5088709163 @default.
- W2155527722 hasAuthorship W2155527722A5090660663 @default.
- W2155527722 hasConcept C104317684 @default.
- W2155527722 hasConcept C105702510 @default.
- W2155527722 hasConcept C142724271 @default.
- W2155527722 hasConcept C153911025 @default.
- W2155527722 hasConcept C174475383 @default.
- W2155527722 hasConcept C206936463 @default.
- W2155527722 hasConcept C2777546739 @default.
- W2155527722 hasConcept C2780474809 @default.
- W2155527722 hasConcept C3019992690 @default.
- W2155527722 hasConcept C30481170 @default.
- W2155527722 hasConcept C502942594 @default.
- W2155527722 hasConcept C53226629 @default.
- W2155527722 hasConcept C54355233 @default.
- W2155527722 hasConcept C71924100 @default.
- W2155527722 hasConcept C81089528 @default.
- W2155527722 hasConcept C86803240 @default.
- W2155527722 hasConceptScore W2155527722C104317684 @default.
- W2155527722 hasConceptScore W2155527722C105702510 @default.
- W2155527722 hasConceptScore W2155527722C142724271 @default.
- W2155527722 hasConceptScore W2155527722C153911025 @default.
- W2155527722 hasConceptScore W2155527722C174475383 @default.
- W2155527722 hasConceptScore W2155527722C206936463 @default.
- W2155527722 hasConceptScore W2155527722C2777546739 @default.
- W2155527722 hasConceptScore W2155527722C2780474809 @default.
- W2155527722 hasConceptScore W2155527722C3019992690 @default.
- W2155527722 hasConceptScore W2155527722C30481170 @default.
- W2155527722 hasConceptScore W2155527722C502942594 @default.
- W2155527722 hasConceptScore W2155527722C53226629 @default.
- W2155527722 hasConceptScore W2155527722C54355233 @default.
- W2155527722 hasConceptScore W2155527722C71924100 @default.
- W2155527722 hasConceptScore W2155527722C81089528 @default.
- W2155527722 hasConceptScore W2155527722C86803240 @default.
- W2155527722 hasIssue "1" @default.
- W2155527722 hasLocation W21555277221 @default.
- W2155527722 hasLocation W21555277222 @default.
- W2155527722 hasOpenAccess W2155527722 @default.
- W2155527722 hasPrimaryLocation W21555277221 @default.
- W2155527722 hasRelatedWork W1970446973 @default.
- W2155527722 hasRelatedWork W1971199955 @default.
- W2155527722 hasRelatedWork W1985862544 @default.
- W2155527722 hasRelatedWork W2003580043 @default.
- W2155527722 hasRelatedWork W2011623472 @default.
- W2155527722 hasRelatedWork W2016228336 @default.
- W2155527722 hasRelatedWork W2061403026 @default.
- W2155527722 hasRelatedWork W2077337512 @default.
- W2155527722 hasRelatedWork W2113424017 @default.
- W2155527722 hasRelatedWork W94008642 @default.
- W2155527722 hasVolume "28" @default.
- W2155527722 isParatext "false" @default.
- W2155527722 isRetracted "false" @default.
- W2155527722 magId "2155527722" @default.
- W2155527722 workType "article" @default.