Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155533522> ?p ?o ?g. }
- W2155533522 endingPage "605" @default.
- W2155533522 startingPage "597" @default.
- W2155533522 abstract "CXCL5 is a member of the CXC-type chemokine family that may play a role in carcinogenesis and cancer progression. This study investigates the biological function and clinical significance of CXCL5 in intrahepatic cholangiocarcinoma (ICC). We demonstrated that CXCL5 was overexpressed in ICC cell lines and tumor samples compared with paired normal tissues. CXCL5 had a direct chemoattractant effect on neutrophils in vitro through PI3K-Akt and extracellular signal-regulated kinase 1/2 signaling pathways. In animal studies, CXCL5 promoted tumor growth and metastasis without altering in vitro proliferative and invasive ability of ICC cells, and this effect was mediated by the recruitment of intratumoral infiltrative neutrophils by tumor-derived CXCL5. Immunohistochemical analysis of ICC samples showed that overexpression of CXCL5 correlated strongly with intratumoral neutrophil infiltration, shorter overall survival and high tumor recurrence. Multivariate analysis revealed that CXCL5 overexpression alone, or combined with the presence of intratumoral neutrophils, was an independent prognostic indicator for ICC. In conclusion, our data showed that CXCL5 promotes ICC growth and metastasis by recruiting intratumoral neutrophils. CXCL5 alone or combined with intratumoral neutrophils is a novel prognostic predictor for ICC patients and a potential therapeutic target." @default.
- W2155533522 created "2016-06-24" @default.
- W2155533522 creator A5003074251 @default.
- W2155533522 creator A5007750245 @default.
- W2155533522 creator A5016159572 @default.
- W2155533522 creator A5017601028 @default.
- W2155533522 creator A5029634246 @default.
- W2155533522 creator A5031371726 @default.
- W2155533522 creator A5036159697 @default.
- W2155533522 creator A5049184934 @default.
- W2155533522 creator A5061703157 @default.
- W2155533522 creator A5068898389 @default.
- W2155533522 creator A5069430086 @default.
- W2155533522 creator A5086674805 @default.
- W2155533522 creator A5089696388 @default.
- W2155533522 date "2013-11-30" @default.
- W2155533522 modified "2023-10-18" @default.
- W2155533522 title "CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils" @default.
- W2155533522 cites W1764421709 @default.
- W2155533522 cites W1970155928 @default.
- W2155533522 cites W1973923070 @default.
- W2155533522 cites W1974887744 @default.
- W2155533522 cites W1975947992 @default.
- W2155533522 cites W1975960651 @default.
- W2155533522 cites W1984086503 @default.
- W2155533522 cites W1991365889 @default.
- W2155533522 cites W1991701933 @default.
- W2155533522 cites W1995651073 @default.
- W2155533522 cites W2002157461 @default.
- W2155533522 cites W2003603007 @default.
- W2155533522 cites W2004635533 @default.
- W2155533522 cites W2013202400 @default.
- W2155533522 cites W2015981241 @default.
- W2155533522 cites W2023164440 @default.
- W2155533522 cites W2024275092 @default.
- W2155533522 cites W2027793117 @default.
- W2155533522 cites W2030499792 @default.
- W2155533522 cites W2030565218 @default.
- W2155533522 cites W2033135582 @default.
- W2155533522 cites W2036709524 @default.
- W2155533522 cites W2036995683 @default.
- W2155533522 cites W2037834427 @default.
- W2155533522 cites W2061556000 @default.
- W2155533522 cites W2068567241 @default.
- W2155533522 cites W2070818071 @default.
- W2155533522 cites W2071394435 @default.
- W2155533522 cites W2072322888 @default.
- W2155533522 cites W2086159554 @default.
- W2155533522 cites W2095033519 @default.
- W2155533522 cites W2117499321 @default.
- W2155533522 cites W2119752261 @default.
- W2155533522 cites W2123105952 @default.
- W2155533522 cites W2123767664 @default.
- W2155533522 cites W2141078344 @default.
- W2155533522 cites W2154695851 @default.
- W2155533522 cites W2162885959 @default.
- W2155533522 cites W2164710273 @default.
- W2155533522 cites W2165948908 @default.
- W2155533522 doi "https://doi.org/10.1093/carcin/bgt397" @default.
- W2155533522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24293410" @default.
- W2155533522 hasPublicationYear "2013" @default.
- W2155533522 type Work @default.
- W2155533522 sameAs 2155533522 @default.
- W2155533522 citedByCount "131" @default.
- W2155533522 countsByYear W21555335222014 @default.
- W2155533522 countsByYear W21555335222015 @default.
- W2155533522 countsByYear W21555335222016 @default.
- W2155533522 countsByYear W21555335222017 @default.
- W2155533522 countsByYear W21555335222018 @default.
- W2155533522 countsByYear W21555335222019 @default.
- W2155533522 countsByYear W21555335222020 @default.
- W2155533522 countsByYear W21555335222021 @default.
- W2155533522 countsByYear W21555335222022 @default.
- W2155533522 countsByYear W21555335222023 @default.
- W2155533522 crossrefType "journal-article" @default.
- W2155533522 hasAuthorship W2155533522A5003074251 @default.
- W2155533522 hasAuthorship W2155533522A5007750245 @default.
- W2155533522 hasAuthorship W2155533522A5016159572 @default.
- W2155533522 hasAuthorship W2155533522A5017601028 @default.
- W2155533522 hasAuthorship W2155533522A5029634246 @default.
- W2155533522 hasAuthorship W2155533522A5031371726 @default.
- W2155533522 hasAuthorship W2155533522A5036159697 @default.
- W2155533522 hasAuthorship W2155533522A5049184934 @default.
- W2155533522 hasAuthorship W2155533522A5061703157 @default.
- W2155533522 hasAuthorship W2155533522A5068898389 @default.
- W2155533522 hasAuthorship W2155533522A5069430086 @default.
- W2155533522 hasAuthorship W2155533522A5086674805 @default.
- W2155533522 hasAuthorship W2155533522A5089696388 @default.
- W2155533522 hasBestOaLocation W21555335221 @default.
- W2155533522 hasConcept C11957725 @default.
- W2155533522 hasConcept C121608353 @default.
- W2155533522 hasConcept C126322002 @default.
- W2155533522 hasConcept C13373296 @default.
- W2155533522 hasConcept C142724271 @default.
- W2155533522 hasConcept C170493617 @default.
- W2155533522 hasConcept C2779013556 @default.
- W2155533522 hasConcept C2779256057 @default.
- W2155533522 hasConcept C502942594 @default.